Septerna, Inc. Common Stock

SEPNNASDAQ • USD
ThemeBiotech - Drug Development›Metabolic & Cardiometabolic
31.15 USD
↘ 0.22 (0.70%)AT CLOSE (11:59 AM EDT)
31.15
↗ 0.01 (0.02%)
POST MARKET (AS OF 04:16 PM EDT)
Post Market
AS OF 04:16 PM EDT
31.15
↗ 0.01 (0.02%)
🔴Market: CLOSED
Open?$30.99
High?$31.41
Low?$30.47
Prev. Close?$31.37
Volume?211.7K
Avg. Volume?323.5K
VWAP?$30.97
Rel. Volume?0.65x
Bid / Ask
Bid?$25.27 × 100
Ask?$36.48 × 100
Spread?$11.21
Midpoint?$30.88
Valuation & Ratios
Market Cap?1.4B
Shares Out?45.1M
Float?26.6M
Float %?59.2%
P/E Ratio?N/A
P/B Ratio?3.71
EPS?-$0.80
Dividend?0.00%
Ex-Dividend?N/A

Septerna, Inc. Common Stock (SEPN) is currently trading at $31.15. The technical outlook is "Strong Buy" and the fundamental picture shows "Neutral". Key drivers include a robust Altman Z-Score, a weak Piotroski F-Score of 0/9, negative Return on Equity, a bullish Golden Cross on the moving averages and bullish moving average alignment. SEPN is fairly valued relative to its sector peers based on current multiples.

Technical & fundamental data as of Jun 5, 2026.

News
Profile
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
Themes
Biotech - Drug Development›Metabolic & CardiometabolicBiotech - Drug Development›Immunology & Autoimmune
Employees
130
Market Cap
1.4B
Industry
PHARMACEUTICAL PREPARATIONS
Website
www.septerna.com
Listed
2024-10-25
Address
250 EAST GRAND AVENUE, SUITE 65
SOUTH SAN FRANCISCO, CA 94080
Phone: 650-338-3533
Technical OutlookStrong Buy
Strong SellNeutralStrong Buy
Long-Term (Tide)?▲ Bullish(+3/3)
Medium-Term (Wave)?▲ Bullish(+2/3)
Short-Term (Ripple)?– Neutral(0/3)
MA Alignment?Golden Alignment
Full Technical Analysis →
Fundamental OutlookNeutral
Strong SellNeutralStrong Buy
F-Score?
3
Z-Score?
95
Momentum?
73
Short Sent.?
24
Piotroski F-Score?0/9Weak
Altman Z-Score?4.32Safe
Confidence?45%Low
Full Fundamental Analysis →
Short InterestHigh
Short % of Float?8.99%Elevated
Short Interest?2.4M
Days to Cover?7.4
Free Float26.6M
Avg Daily Volume321.9K
Settlement Date2026-05-15
Financial Health
Current Ratio?4.71Strong
Quick Ratio?4.71Strong
Cash Ratio?0.92Adequate
Debt/Equity?0.00Low
ValuationFAIRLY VALUEDvs 1 peers + S&P 500
Score
67/100
P/E?
N/A▾
P/B?
Peers
100
S&P
47
3.71FAIR▾
P/S?
Peers
100
S&P
3
19.43HIGH▾
P/FCF?
Peers
100
S&P
80
13.1CHEAP▾
EV/EBITDA?
S&P
97
-20.0CHEAP▾
EV/Sales?
Peers
100
S&P
3
18.44HIGH▾
Returns & Efficiency
ROE?
S&P
9
-9.5%WEAK▾
ROA?
S&P
3
-6.3%WEAK▾
Cash Flow & Enterprise
FCF?$106.9M
Enterprise Value?$1.3B
Fundamentals ratios updated end of day
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