| Eli Lilly & Co. | Metabolic & Cardiometabolic | $1.0t | $1153.79 | +0.1% | 1.8M | |
| Johnson & Johnson | Immunology & Autoimmune | $0.7t | $270.02 | -0.1% | 6.3M | |
| ABBVIE INC. | Immunology & Autoimmune | $462.5b | $264.50 | -0.0% | 3.2M | |
| Merck & Co., Inc. | Infectious Disease & Vaccines | $375.8b | $146.57 | -0.4% | 6.5M | |
| AstraZeneca PLC | Metabolic & Cardiometabolic | $250.7b | $167.15 | +0.3% | 2.6M | |
| Amgen Inc | Rare Disease TherapeuticsImmunology & Autoimmune | $239.4b | $385.38 | +1.5% | 3.0M | |
| Thermo Fisher Scientific, Inc. | Clinical-Stage Platforms | $228.7b | $652.29 | -1.1% | 2.3M | |
| Gilead Sciences Inc | Infectious Disease & Vaccines | $185.5b | $149.90 | -0.6% | 6.8M | |
| Pfizer Inc. | Infectious Disease & Vaccines | $164.2b | $27.61 | -0.1% | 23.9M | |
| Vertex Pharmaceuticals Inc | Rare Disease Therapeutics | $141.4b | $506.78 | -1.6% | 987.0K | |
| Bristol-Myers Squibb Co. | Immunology & Autoimmune | $138.2b | $62.92 | +0.1% | 9.3M | |
| Regeneron Pharmaceuticals Inc | Immunology & Autoimmune | $86.8b | $784.57 | -0.6% | 495.9K | |
| Moderna, Inc. Common Stock | Infectious Disease & Vaccines | $59.4b | $153.90 | -2.6% | 9.2M | |
| IQVIA Holdings Inc. | Clinical-Stage Platforms | $43.4b | $261.31 | -1.1% | 2.0M | |
| Agilent Technologies Inc. | Clinical-Stage Platforms | $42.7b | $158.63 | +2.3% | 1.8M | |
| Waters Corp | Clinical-Stage Platforms | $40.6b | $423.39 | -1.9% | 463.6K | |
| Alnylam Pharmaceuticals, Inc. | Rare Disease Therapeutics | $35.8b | $239.62 | -2.4% | 1.4M | |
| Biogen Inc. Common Stock | Neuroscience & CNS | $32.9b | $217.00 | -1.5% | 880.0K | |
| Royalty Pharma plc Class A Ordinary Shares | Clinical-Stage Platforms | $28.4b | $58.70 | -0.9% | 1.7M | |
| Insmed, Inc. | Rare Disease Therapeutics | $27.7b | $120.48 | -3.2% | 2.1M | |
| Incyte Genomics Inc | Rare Disease Therapeutics | $26.1b | $125.91 | -1.8% | 1.3M | |
| Roivant Sciences Ltd. Common Shares | Immunology & Autoimmune | $24.9b | $40.33 | -0.4% | 7.6M | |
| West Pharmaceutical Services, Inc. | Clinical-Stage Platforms | $24.1b | $362.14 | -1.2% | 377.6K | |
| United Therapeutics Corp | Rare Disease Therapeutics | $21.0b | $494.73 | -0.5% | 373.2K | |
| Ascendis Pharma A/S Ordinary Share | Clinical-Stage Platforms | $17.5b | $238.46 | -0.9% | 703.0K | |
| Medpace Holdings, Inc. Common Stock | Clinical-Stage Platforms | $16.6b | $576.94 | -0.4% | 166.9K | |
| Neurocrine Biosciences Inc | Neuroscience & CNS | $16.1b | $146.57 | -3.7% | 1.1M | |
| Jazz Pharmaceuticals, Inc. | Neuroscience & CNS | $15.9b | $237.74 | -1.3% | 503.6K | |
| BridgeBio Pharma, Inc. Common Stock | Rare Disease Therapeutics | $15.0b | $66.64 | -1.1% | 1.9M | |
| Revvity, Inc. | Clinical-Stage Platforms | $14.6b | $144.71 | -2.2% | 2.1M | |
| Charles River Laboratories International, Inc. | Clinical-Stage Platforms | $13.9b | $277.84 | -1.3% | 603.2K | |
| Summit Therapeutics Inc. Common Stock | Infectious Disease & Vaccines | $13.7b | $17.79 | +0.6% | 3.5M | |
| BioMarin Pharmaceuticals Inc | Rare Disease Therapeutics | $13.0b | $63.90 | -1.8% | 1.6M | |
| Madrigal Pharmaceuticals, Inc. Common Stock | Metabolic & Cardiometabolic | $12.5b | $531.48 | -0.6% | 152.3K | |
| Halozyme Therapeutics, Inc. | Clinical-Stage Platforms | $12.4b | $113.00 | +2.6% | 8.3M | |
| Icon Plc | Clinical-Stage Platforms | $12.3b | $164.11 | -3.4% | 911.9K | |
| Arrowhead Research Corporation | Rare Disease Therapeutics | $12.1b | $66.97 | -1.7% | 1.8M | |
| Corcept Therapeutics Inc. | Rare Disease Therapeutics | $11.9b | $111.28 | -3.9% | 2.0M | |
| Bio-Techne Corp. | Clinical-Stage Platforms | $11.4b | $72.28 | -0.0% | 2.9M | |
| Axsome Therapeutics, Inc | Neuroscience & CNS | $11.0b | $207.16 | -3.0% | 444.3K | |
| Krystal Biotech, Inc. Common Stock | Rare Disease Therapeutics | $10.9b | $340.88 | -0.6% | 208.4K | |
| Apogee Therapeutics, Inc. Common Stock | Immunology & Autoimmune | $10.2b | $135.09 | 0.0% | N/A | |
| Ionis Pharmaceuticals, Inc. Common Stock | Rare Disease Therapeutics | $10.2b | $44.59 | -5.0% | 3.4M | |
| Cytokinetics Inc. | Rare Disease TherapeuticsNeuroscience & CNS | $10.0b | $68.83 | -1.7% | 1.3M | |
| Praxis Precision Medicines, Inc. Common Stock | Neuroscience & CNS | $9.9b | $297.79 | -3.7% | 572.7K | |
| Avantor, Inc. | Clinical-Stage Platforms | $9.9b | $15.52 | -2.2% | 9.2M | |
| Kymera Therapeutics, Inc. Common Stock | Clinical-Stage Platforms | $9.9b | $117.75 | -0.6% | 542.4K | |
| Protagonist Therapeutics, Inc | Metabolic & CardiometabolicImmunology & Autoimmune | $9.6b | $143.03 | -0.5% | 477.5K | |
| Repligen Corp | Clinical-Stage Platforms | $9.6b | $176.90 | -0.7% | 675.3K | |
| Vaxcyte, Inc. Common Stock | Infectious Disease & Vaccines | $9.1b | $58.10 | -3.7% | 1.3M |