| Eli Lilly & Co. | Metabolic & Cardiometabolic | $1.0t | $1416.97 | +3.2% | 3.9M | |
| Johnson & Johnson | Immunology & Autoimmune | $0.6t | $274.04 | -0.7% | 5.5M | |
| ABBVIE INC. | Immunology & Autoimmune | $464.4b | $294.17 | +1.4% | 4.5M | |
| Merck & Co., Inc. | Infectious Disease & Vaccines | $356.0b | $149.59 | +2.2% | 8.6M | |
| AstraZeneca PLC | Metabolic & Cardiometabolic | $243.3b | $185.85 | +7.0% | 5.0M | |
| Thermo Fisher Scientific, Inc. | Clinical-Stage Platforms | $242.1b | $695.13 | -1.8% | 1.6M | |
| Amgen Inc | Immunology & AutoimmuneRare Disease Therapeutics | $217.9b | $466.00 | +1.2% | 2.3M | |
| Gilead Sciences Inc | Infectious Disease & Vaccines | $179.5b | $170.50 | +3.2% | 8.8M | |
| Pfizer Inc. | Infectious Disease & Vaccines | $158.5b | $30.45 | +1.7% | 28.8M | |
| Vertex Pharmaceuticals Inc | Rare Disease Therapeutics | $127.9b | $553.72 | +3.5% | 2.3M | |
| Bristol-Myers Squibb Co. | Immunology & Autoimmune | $124.9b | $62.40 | +1.8% | 8.3M | |
| Moderna, Inc. Common Stock | Infectious Disease & Vaccines | $75.9b | $221.40 | -0.5% | 7.7M | |
| Regeneron Pharmaceuticals Inc | Immunology & Autoimmune | $75.7b | $928.00 | +13.3% | 2.5M | |
| Agilent Technologies Inc. | Clinical-Stage Platforms | $47.3b | $174.06 | -3.5% | 2.2M | |
| IQVIA Holdings Inc. | Clinical-Stage Platforms | $42.5b | $268.65 | -2.8% | 827.1K | |
| Waters Corp | Clinical-Stage Platforms | $41.8b | $462.69 | -3.6% | 1.1M | |
| Biogen Inc. Common Stock | Neuroscience & CNS | $32.5b | $253.69 | +1.6% | 1.0M | |
| Alnylam Pharmaceuticals, Inc. | Rare Disease Therapeutics | $29.4b | $165.73 | -5.2% | 6.3M | |
| Roivant Sciences Ltd. Common Shares | Immunology & Autoimmune | $25.8b | $33.94 | -1.6% | 3.4M | |
| West Pharmaceutical Services, Inc. | Clinical-Stage Platforms | $25.7b | $412.81 | -1.0% | 837.2K | |
| Royalty Pharma plc Class A Ordinary Shares | Clinical-Stage Platforms | $25.5b | $67.33 | +1.9% | 4.0M | |
| Insmed, Inc. | Rare Disease Therapeutics | $24.3b | $113.22 | +0.9% | 3.6M | |
| Incyte Genomics Inc | Rare Disease Therapeutics | $23.4b | $120.42 | +3.1% | 2.2M | |
| United Therapeutics Corp | Rare Disease Therapeutics | $23.2b | $598.08 | +0.9% | 388.7K | |
| Revvity, Inc. | Clinical-Stage Platforms | $16.9b | $160.00 | -5.3% | 2.7M | |
| Medpace Holdings, Inc. Common Stock | Clinical-Stage Platforms | $16.7b | $645.97 | -3.8% | 157.6K | |
| Jazz Pharmaceuticals, Inc. | Neuroscience & CNS | $15.3b | $208.50 | +4.0% | 944.3K | |
| Ascendis Pharma A/S Ordinary Share | Clinical-Stage Platforms | $15.0b | $251.34 | -0.7% | 336.5K | |
| Neurocrine Biosciences Inc | Neuroscience & CNS | $14.6b | $142.81 | -0.1% | 850.7K | |
| Charles River Laboratories International, Inc. | Clinical-Stage Platforms | $13.9b | $373.11 | -2.9% | 1.3M | |
| Summit Therapeutics Inc. Common Stock | Infectious Disease & Vaccines | $13.4b | $15.95 | -1.0% | 3.1M | |
| BridgeBio Pharma, Inc. Common Stock | Rare Disease Therapeutics | $13.1b | $74.65 | +6.0% | 5.1M | |
| Corcept Therapeutics Inc. | Rare Disease Therapeutics | $12.6b | $86.32 | -5.6% | 1.2M | |
| Twist Bioscience Corporation Common Stock | Clinical-Stage Platforms | $12.5b | $152.56 | -12.0% | 3.2M | |
| Icon Plc | Clinical-Stage Platforms | $12.5b | $211.19 | -2.0% | 2.4M | |
| Halozyme Therapeutics, Inc. | Clinical-Stage Platforms | $12.5b | $131.54 | -0.2% | 1.1M | |
| Madrigal Pharmaceuticals, Inc. Common Stock | Metabolic & Cardiometabolic | $11.5b | $434.50 | -0.3% | 211.5K | |
| Bio-Techne Corp. | Clinical-Stage Platforms | $11.4b | $72.70 | -0.0% | 2.2M | |
| BioMarin Pharmaceuticals Inc | Rare Disease Therapeutics | $11.1b | $58.53 | +1.8% | 1.7M | |
| ImmunityBio, Inc. Common Stock | Immunology & Autoimmune | $10.9b | $8.27 | -5.1% | 7.9M | |
| Avantor, Inc. | Clinical-Stage Platforms | $10.4b | $15.93 | -4.9% | 8.2M | |
| Repligen Corp | Clinical-Stage Platforms | $10.3b | $176.94 | -6.3% | 4.2M | |
| Apogee Therapeutics, Inc. Common Stock | Immunology & Autoimmune | $10.2b | $135.09 | 0.0% | N/A | |
| Bruker Corporation | Clinical-Stage Platforms | $9.6b | $57.15 | -7.9% | 1.6M | |
| Krystal Biotech, Inc. Common Stock | Rare Disease Therapeutics | $9.5b | $332.33 | +2.3% | 216.4K | |
| Axsome Therapeutics, Inc | Neuroscience & CNS | $9.4b | $146.56 | +0.8% | 1.9M | |
| QIAGEN N.V. | Clinical-Stage Platforms | $9.2b | $50.93 | -0.2% | 4.0M | |
| Cytokinetics Inc. | Rare Disease TherapeuticsNeuroscience & CNS | $9.1b | $63.50 | -0.4% | 898.4K | |
| Arrowhead Research Corporation | Rare Disease Therapeutics | $9.1b | $59.41 | -1.0% | 914.0K | |
| Protagonist Therapeutics, Inc | Immunology & AutoimmuneMetabolic & Cardiometabolic | $9.1b | $144.90 | +0.3% | 202.2K |