| AstraZeneca PLC | Precision Medicine Platforms | $263.1b | $157.22 | +1.0% | 73.4K | |
| Thermo Fisher Scientific, Inc. | Precision Medicine Platforms | $212.2b | $560.72 | +0.4% | 239 | |
| Danaher Corporation | Precision Medicine Platforms | $137.1b | $195.48 | +0.6% | 472 | |
| Vertex Pharmaceuticals Inc | Gene Therapy & Gene Editing | $119.5b | $484.14 | 0.0% | 424 | |
| Regeneron Pharmaceuticals Inc | Gene Therapy & Gene Editing | $78.2b | $759.00 | 0.0% | 135 | |
| Natera, Inc. Common Stock | Genetic Testing & Diagnostics | $38.7b | $280.46 | 0.0% | 326 | |
| Waters Corp | Precision Medicine Platforms | $36.8b | $400.20 | +1.0% | 2.8K | |
| Illumina Inc | Genetic Testing & Diagnostics | $31.0b | $202.78 | 0.0% | 480 | |
| Alnylam Pharmaceuticals, Inc. | RNA Therapeutics | $27.5b | $219.12 | 0.0% | 286 | |
| Labcorp Holdings Inc. | Genetic Testing & Diagnostics | $25.0b | $306.95 | -0.0% | 1.9K | |
| Guardant Health, Inc. Common Stock | Precision Medicine Platforms | $21.7b | $161.11 | 0.0% | 193 | |
| Insmed, Inc. | Gene Therapy & Gene Editing | $21.4b | $98.89 | 0.0% | 1.1K | |
| BridgeBio Pharma, Inc. Common Stock | Precision Medicine Platforms | $15.7b | $83.92 | 0.0% | 599 | |
| Revvity, Inc. | Precision Medicine Platforms | $12.9b | $111.67 | -0.5% | 574 | |
| Arrowhead Research Corporation | RNA Therapeutics | $11.9b | $90.25 | 0.0% | 196 | |
| BioMarin Pharmaceuticals Inc | Gene Therapy & Gene Editing | $11.6b | $61.30 | 0.0% | 1.2K | |
| Bio-Techne Corp. | Precision Medicine Platforms | $11.2b | $72.28 | 0.0% | N/A | |
| Krystal Biotech, Inc. Common Stock | Gene Therapy & Gene Editing | $10.1b | $335.51 | 0.0% | 3 | |
| Nuvalent, Inc. Class A Common Stock | Precision Medicine Platforms | $9.8b | $123.96 | 0.0% | N/A | |
| QIAGEN N.V. | Genetic Testing & Diagnostics | $8.7b | $42.08 | -0.8% | 1.6K | |
| Ionis Pharmaceuticals, Inc. Common Stock | RNA Therapeutics | $8.6b | $54.95 | 0.0% | 388 | |
| Praxis Precision Medicines, Inc. Common Stock | Precision Medicine Platforms | $8.5b | $307.25 | 0.0% | 9 | |
| Kymera Therapeutics, Inc. Common Stock | Precision Medicine Platforms | $8.5b | $111.08 | 0.0% | 1.4K | |
| Tempus AI, Inc. Class A Common Stock | Precision Medicine Platforms | $8.3b | $47.10 | 0.0% | 57.9K | |
| Lantheus Holdings, Inc | Precision Medicine Platforms | $6.5b | $101.56 | 0.0% | 49 | |
| BillionToOne, Inc. Class A Common Stock | Genetic Testing & Diagnostics | $6.4b | $141.97 | 0.0% | 78 | |
| Twist Bioscience Corporation Common Stock | Precision Medicine Platforms | $6.3b | $100.00 | 0.0% | 3.7K | |
| 10x Genomics, Inc. Class A Common Stock | Genetic Testing & Diagnostics | $6.0b | $47.74 | 0.0% | 891 | |
| CRISPR Therapeutics AG | Gene Therapy & Gene Editing | $4.7b | $52.94 | 0.0% | 2.1K | |
| Dyne Therapeutics, Inc. Common Stock | Precision Medicine Platforms | $4.7b | $26.31 | 0.0% | 1.3K | |
| Amicus Therapeutics, Inc | Gene Therapy & Gene Editing | $4.5b | $14.49 | +0.0% | 3.5M | |
| Caris Life Sciences, Inc. Common Stock | Precision Medicine Platforms | $4.4b | $16.38 | 0.0% | 1.7K | |
| Veracyte, Inc. | Genetic Testing & Diagnostics | $3.6b | $46.97 | 0.0% | 9 | |
| Adaptive Biotechnologies Corporation Common Stock | Precision Medicine Platforms | $3.6b | $24.64 | 0.0% | 362 | |
| IDEAYA Biosciences, Inc. Common Stock | Precision Medicine Platforms | $3.4b | $36.47 | 0.0% | 9 | |
| uniQure N.V. | Gene Therapy & Gene Editing | $3.1b | $43.34 | 0.0% | 594 | |
| Beam Therapeutics Inc. Common Stock | Gene Therapy & Gene Editing | $2.6b | $28.43 | 0.0% | 765 | |
| Vericel Corporation | Gene Therapy & Gene Editing | $2.4b | $46.76 | 0.0% | N/A | |
| Precigen, Inc. Common Stock | Gene Therapy & Gene Editing | $2.4b | $7.33 | 0.0% | 21.7K | |
| CareDx, Inc. | Genetic Testing & DiagnosticsPrecision Medicine Platforms | $2.3b | $47.39 | 0.0% | 5.3K | |
| NeoGenomics, Inc. | Genetic Testing & Diagnostics | $2.0b | $16.46 | 0.0% | 2.2K | |
| GeneDx Holdings Corp. Class A Common Stock | Genetic Testing & DiagnosticsPrecision Medicine Platforms | $2.0b | $71.33 | 0.0% | 762 | |
| Sarepta Therapeutics,, Inc. Common Stock | Gene Therapy & Gene Editing | $1.7b | $16.48 | 0.0% | 8.5K | |
| Taysha Gene Therapies, Inc. Common Stock | Gene Therapy & Gene Editing | $1.7b | $6.18 | 0.0% | 790 | |
| BioLife Solutions Inc. | Gene Therapy & Gene Editing | $1.5b | $32.75 | 0.0% | 607 | |
| Maze Therapeutics, Inc. Common Stock | Precision Medicine Platforms | $1.5b | $27.60 | 0.0% | N/A | |
| Intellia Therapeutics, Inc | Gene Therapy & Gene Editing | $1.5b | $11.36 | 0.0% | 18.2K | |
| Personalis, Inc. Common Stock | Genetic Testing & Diagnostics | $1.4b | $13.44 | 0.0% | 744 | |
| Azenta, Inc. | Genetic Testing & Diagnostics | $1.3b | $30.20 | 0.0% | 111 | |
| Wave Life Sciences Ltd. Ordinary Shares | RNA Therapeutics | $1.1b | $5.92 | 0.0% | 243 |