87.89 USD
↘ 0.78 (0.88%)AT CLOSE (11:59 AM EDT)
Spyre Therapeutics, Inc. Common Stock
SYRENASDAQ • USD
87.88
↘ 0.02 (0.02%)
POST MARKET (AS OF 07:38 PM EDT)
Post Market
AS OF 07:38 PM EDT
87.88
↘ 0.02 (0.02%)
Market: CLOSED
Shares of Spyre Therapeutics, Inc. Common Stock (SYRE) are trading at $87.89. There is a divergence between signals — technical indicators rate "Strong Buy" but underlying fundamentals lean "Sell". Notable factors include a robust Altman Z-Score, a weak Piotroski F-Score of 0/9, negative Return on Equity, a bullish Golden Cross on the moving averages and bullish moving average alignment. Valuation-wise, the stock is priced at a premium — multiples like P/E and EV/EBITDA sit above sector averages.
Technical & fundamental data as of Jun 26, 2026.
Open?$91.00
High?$91.00
Low?$85.97
Prev. Close?$88.67
Volume?4.4M
Avg. Volume?1.5M
VWAP?$87.64
Rel. Volume?3.01x
Bid / Ask
Bid?$88.00 × 1.0K
Ask?$88.85 × 1.0K
Spread?$0.85
Midpoint?$88.43
Valuation & Ratios
Market Cap?7.6B
Shares Out?86.8M
Float?66.9M
Float %?85.2%
P/E Ratio?N/A
P/B Ratio?11.38
EPS?-$1.71
Dividend?0.00%
Ex-Dividend?N/A
News
Profile
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
Address
221 CRESCENT STREET
WALTHAM, MA 02453
Phone: (617) 651-5940
WALTHAM, MA 02453
Phone: (617) 651-5940
Technical OutlookStrong Buy
Strong SellNeutralStrong Buy
Long-Term (Tide)?▲ Bullish(+3/3)
Medium-Term (Wave)?▲ Bullish(+2/3)
Short-Term (Ripple)?▼ Bearish(-2/3)
MA Alignment?Golden Alignment
Full Technical Analysis →Fundamental OutlookSell
Strong SellNeutralStrong Buy
F-Score?3
Z-Score?100
Momentum?50
Short Sent.?19
Piotroski F-Score?0/9Weak
Altman Z-Score?47.00Safe
Confidence?49%Low
Short InterestVery High
Short % of Float?18.87%High
Short Interest?12.6M
Days to Cover?10.8
Free Float66.9M
Avg Daily Volume1.2M
Settlement Date2026-06-15
Financial Health
Current Ratio?8.97Strong
Quick Ratio?8.97Strong
Cash Ratio?1.14Strong
Debt/Equity?0.00Low
ValuationFAIRLY VALUEDvs 1 peers + S&P 500
Score67/100
P/E?N/A▾
P/B?11.38HIGH▾
Peers100
S&P17
P/S?N/A▾
P/FCF?N/A▾
EV/EBITDA?-31.2CHEAP▾
S&P97
EV/Sales?N/A▾
Returns & Efficiency
ROE?-22.2%WEAK▾
S&P7
ROA?-19.5%WEAK▾
S&P3
Cash Flow & Enterprise
FCF?N/A
Enterprise Value?$7.5B
Fundamentals ratios updated end of day