99.05 USD
↗ 6.14 (6.60%)AT CLOSE (03:59 PM EDT)
Spyre Therapeutics, Inc. Common Stock
SYRENASDAQ • USD
99.06
↗ 0.01 (0.01%)
POST MARKET (AS OF 07:47 PM EDT)
Post Market
AS OF 07:47 PM EDT
99.06
↗ 0.01 (0.01%)
Market: CLOSED
Shares of Spyre Therapeutics, Inc. Common Stock (SYRE) are trading at $99.05. The technical outlook is "Strong Buy" and the fundamental picture shows "Neutral". Notable factors include a robust Altman Z-Score, a weak Piotroski F-Score of 0/9, negative Return on Equity and a bullish Golden Cross on the moving averages. Valuation metrics place SYRE at a fair price relative to peers.
Technical & fundamental data as of Oct 27, 2026.
Open?$93.00
High?$99.24
Low?$92.37
Prev. Close?$92.91
Volume?944.9K
Avg. Volume?1.4M
VWAP?$97.24
Rel. Volume?0.65x
Bid / Ask
Bid?$83.95 × 100
Ask?$112.34 × 100
Spread?$28.39
Midpoint?$98.15
Valuation & Ratios
Market Cap?8.7B
Shares Out?101.9M
Float?80.1M
Float %?91.1%
P/E Ratio?N/A
P/B Ratio?7.89
EPS?-$1.61
Dividend?0.00%
Ex-Dividend?N/A
News
Profile
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
Address
221 CRESCENT STREET
WALTHAM, MA 02453
Phone: (617) 651-5940
WALTHAM, MA 02453
Phone: (617) 651-5940
Technical OutlookStrong Buy
Strong SellNeutralStrong Buy
Long-Term (Tide)?▲ Bullish(+3/3)
Medium-Term (Wave)?▲ Bullish(+2/3)
Short-Term (Ripple)?▲ Bullish(+3/3)
MA Alignment?Mixed
Full Technical Analysis →Fundamental OutlookNeutral
Strong SellNeutralStrong Buy
F-Score?3
Z-Score?100
Momentum?50
Short Sent.?25
Piotroski F-Score?0/9Weak
Altman Z-Score?71.39Safe
Confidence?52%Low
Short InterestHigh
Short % of Float?15.60%High
Short Interest?12.5M
Days to Cover?7.3
Free Float80.1M
Avg Daily Volume1.7M
Settlement Date2026-10-15
Financial Health
Current Ratio?18.53Strong
Quick Ratio?18.53Strong
Cash Ratio?2.56Strong
Debt/Equity?0.00Low
ValuationATTRACTIVELY VALUEDvs 1 peers + S&P 500
Score83/100
P/E?N/A▾
P/B?7.89FAIR▾
Peers100
S&P24
P/S?N/A▾
P/FCF?N/A▾
EV/EBITDA?-31.4CHEAP▾
S&P97
EV/Sales?N/A▾
Returns & Efficiency
ROE?-13.6%WEAK▾
S&P9
ROA?-12.8%WEAK▾
S&P3
Cash Flow & Enterprise
FCF?$-208944000
Enterprise Value?$8.5B
Fundamentals ratios updated end of day