73.65 USD
↘ 4.83 (6.15%)AT CLOSE (11:59 AM EDT)
Spyre Therapeutics, Inc. Common Stock
SYRENASDAQ • USD
73.50
↘ 0.15 (0.20%)
POST MARKET (AS OF 07:59 PM EDT)
Post Market
AS OF 07:59 PM EDT
73.50
↘ 0.15 (0.20%)
Market: CLOSED
Open?$77.77
High?$78.90
Low?$73.06
Prev. Close?$78.48
Volume?1.5M
Avg. Volume?1.1M
VWAP?$75.39
Rel. Volume?1.39x
Bid / Ask
Bid?$63.99 × 100
Ask?$84.34 × 100
Spread?$20.35
Midpoint?$74.17
Valuation & Ratios
Market Cap?6.4B
Shares Out?86.8M
Float?66.9M
Float %?85.2%
P/E Ratio?N/A
P/B Ratio?9.53
EPS?-$1.71
Dividend?0.00%
Ex-Dividend?N/A
Shares of Spyre Therapeutics, Inc. Common Stock (SYRE) are trading at $73.65. There is a divergence between signals — technical indicators rate "Buy" but underlying fundamentals lean "Sell". Notable factors include a robust Altman Z-Score, a weak Piotroski F-Score of 0/9, negative Return on Equity, a bullish Golden Cross on the moving averages and bullish moving average alignment. Valuation-wise, the stock is priced at a premium — multiples like P/E and EV/EBITDA sit above sector averages.
Technical & fundamental data as of Jun 5, 2026.
News
Profile
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
Address
221 CRESCENT STREET
WALTHAM, MA 02453
Phone: (617) 651-5940
WALTHAM, MA 02453
Phone: (617) 651-5940
Technical OutlookBuy
Strong SellNeutralStrong Buy
Long-Term (Tide)?▲ Bullish(+2/3)
Medium-Term (Wave)?– Neutral(0/3)
Short-Term (Ripple)?– Neutral(0/3)
MA Alignment?Golden Alignment
Full Technical Analysis →Fundamental OutlookSell
Strong SellNeutralStrong Buy
F-Score?3
Z-Score?100
Momentum?50
Short Sent.?19
Piotroski F-Score?0/9Weak
Altman Z-Score?39.03Safe
Confidence?49%Low
Short InterestVery High
Short % of Float?18.57%High
Short Interest?12.4M
Days to Cover?10.4
Free Float66.9M
Avg Daily Volume1.2M
Settlement Date2026-05-15
Financial Health
Current Ratio?8.97Strong
Quick Ratio?8.97Strong
Cash Ratio?1.14Strong
Debt/Equity?0.00Low
ValuationFAIRLY VALUEDvs 1 peers + S&P 500
Score67/100
P/E?N/A▾
P/B?9.53HIGH▾
Peers100
S&P20
P/S?N/A▾
P/FCF?N/A▾
EV/EBITDA?-26.1CHEAP▾
S&P97
EV/Sales?N/A▾
Returns & Efficiency
ROE?-22.2%WEAK▾
S&P7
ROA?-19.5%WEAK▾
S&P3
Cash Flow & Enterprise
FCF?N/A
Enterprise Value?$6.3B
Fundamentals ratios updated end of day