80.85 USD
↗ 0.74 (0.92%)AT CLOSE (03:59 PM EDT)
Spyre Therapeutics, Inc. Common Stock
SYRENASDAQ • USD
81.92
↗ 1.07 (1.32%)
POST MARKET (AS OF 07:51 PM EDT)
Post Market
AS OF 07:51 PM EDT
81.92
↗ 1.07 (1.32%)
Market: CLOSED
Shares of Spyre Therapeutics, Inc. Common Stock (SYRE) are trading at $80.83. Technical and fundamental signals converge bearish — technicals rate "Strong Sell" while fundamentals read "Sell". Notable factors include a robust Altman Z-Score, a weak Piotroski F-Score of 0/9, negative Return on Equity and a bullish Golden Cross on the moving averages. Valuation metrics place SYRE at a fair price relative to peers.
Technical & fundamental data as of Oct 7, 2026.
Open?$78.91
High?$82.22
Low?$78.00
Prev. Close?$80.11
Volume?2.7M
Avg. Volume?1.4M
VWAP?$80.89
Rel. Volume?1.90x
Bid / Ask
Bid?$52.03 × 100
Ask?$94.62 × 100
Spread?$42.59
Midpoint?$73.33
Valuation & Ratios
Market Cap?7.1B
Shares Out?87.9M
Float?80.4M
Float %?91.4%
P/E Ratio?N/A
P/B Ratio?6.41
EPS?-$1.70
Dividend?0.00%
Ex-Dividend?N/A
News
Profile
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
Address
221 CRESCENT STREET
WALTHAM, MA 02453
Phone: (617) 651-5940
WALTHAM, MA 02453
Phone: (617) 651-5940
Technical OutlookStrong Sell
Strong SellNeutralStrong Buy
Long-Term (Tide)?▼ Bearish(-1/3)
Medium-Term (Wave)?▼ Bearish(-3/3)
Short-Term (Ripple)?▼ Bearish(-2/3)
MA Alignment?Mixed
Full Technical Analysis →Fundamental OutlookSell
Strong SellNeutralStrong Buy
F-Score?3
Z-Score?100
Momentum?50
Short Sent.?19
Piotroski F-Score?0/9Weak
Altman Z-Score?57.88Safe
Confidence?52%Low
Short InterestVery High
Short % of Float?15.09%High
Short Interest?12.1M
Days to Cover?11.6
Free Float80.4M
Avg Daily Volume1.0M
Settlement Date2026-09-15
Financial Health
Current Ratio?18.53Strong
Quick Ratio?18.53Strong
Cash Ratio?2.56Strong
Debt/Equity?0.00Low
ValuationATTRACTIVELY VALUEDvs 1 peers + S&P 500
Score83/100
P/E?N/A▾
P/B?6.41FAIR▾
Peers100
S&P29
P/S?N/A▾
P/FCF?N/A▾
EV/EBITDA?-25.4CHEAP▾
S&P97
EV/Sales?N/A▾
Returns & Efficiency
ROE?-13.6%WEAK▾
S&P9
ROA?-12.8%WEAK▾
S&P3
Cash Flow & Enterprise
FCF?$-208944000
Enterprise Value?$6.9B
Fundamentals ratios updated end of day