91.17 USD
↗ 0.22 (0.24%)AT CLOSE (11:59 AM EDT)
Spyre Therapeutics, Inc. Common Stock
SYRENASDAQ • USD
91.19
↗ 0.02 (0.02%)
POST MARKET (AS OF 07:30 PM EDT)
Post Market
AS OF 07:30 PM EDT
91.19
↗ 0.02 (0.02%)
Market: CLOSED
Shares of Spyre Therapeutics, Inc. Common Stock (SYRE) are trading at $91.21. The technical outlook is "Sell" and the fundamental picture shows "Neutral". Notable factors include a robust Altman Z-Score, a weak Piotroski F-Score of 0/9, negative Return on Equity and a bullish Golden Cross on the moving averages. Valuation metrics place SYRE at a fair price relative to peers.
Technical & fundamental data as of Sep 16, 2026.
Open?$91.38
High?$93.07
Low?$90.48
Prev. Close?$90.95
Volume?1.3M
Avg. Volume?1.0M
VWAP?$91.41
Rel. Volume?1.22x
Bid / Ask
Bid?$77.44 × 100
Ask?$104.88 × 100
Spread?$27.44
Midpoint?$91.16
Valuation & Ratios
Market Cap?8.0B
Shares Out?87.9M
Float?75.4M
Float %?86.8%
P/E Ratio?N/A
P/B Ratio?7.28
EPS?-$1.70
Dividend?0.00%
Ex-Dividend?N/A
News
Profile
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
Address
221 CRESCENT STREET
WALTHAM, MA 02453
Phone: (617) 651-5940
WALTHAM, MA 02453
Phone: (617) 651-5940
Technical OutlookSell
Strong SellNeutralStrong Buy
Long-Term (Tide)?▼ Bearish(-1/3)
Medium-Term (Wave)?▼ Bearish(-1/3)
Short-Term (Ripple)?▲ Bullish(+2/3)
MA Alignment?Mixed
Full Technical Analysis →Fundamental OutlookNeutral
Strong SellNeutralStrong Buy
F-Score?3
Z-Score?100
Momentum?50
Short Sent.?25
Piotroski F-Score?0/9Weak
Altman Z-Score?65.86Safe
Confidence?52%Low
Short InterestHigh
Short % of Float?15.74%High
Short Interest?11.9M
Days to Cover?9.7
Free Float75.4M
Avg Daily Volume1.2M
Settlement Date2026-08-31
Financial Health
Current Ratio?18.53Strong
Quick Ratio?18.53Strong
Cash Ratio?2.56Strong
Debt/Equity?0.00Low
ValuationATTRACTIVELY VALUEDvs 1 peers + S&P 500
Score83/100
P/E?N/A▾
P/B?7.28FAIR▾
Peers100
S&P26
P/S?N/A▾
P/FCF?N/A▾
EV/EBITDA?-29.0CHEAP▾
S&P97
EV/Sales?N/A▾
Returns & Efficiency
ROE?-13.6%WEAK▾
S&P9
ROA?-12.8%WEAK▾
S&P3
Cash Flow & Enterprise
FCF?$-208944000
Enterprise Value?$7.9B
Fundamentals ratios updated end of day