Protagonist Therapeutics, Inc

PTGXNASDAQ • USD
ThemeBiotech - Drug Development›Metabolic & Cardiometabolic
97.38 USD
↘ 5.41 (5.26%)AT CLOSE (11:59 AM EDT)
98.71
↗ 1.33 (1.37%)
POST MARKET (AS OF 05:40 PM EDT)
Post Market
AS OF 05:40 PM EDT
98.71
↗ 1.33 (1.37%)
🔴Market: CLOSED
Open?$103.14
High?$103.29
Low?$96.38
Prev. Close?$102.79
Volume?887.4K
Avg. Volume?588.0K
VWAP?$98.78
Rel. Volume?1.51x
Bid / Ask
Bid?$84.36 × 100
Ask?$111.75 × 100
Spread?$27.39
Midpoint?$98.06
Valuation & Ratios
Market Cap?6.3B
Shares Out?64.3M
Float?59.7M
Float %?93.6%
P/E Ratio?N/A
P/B Ratio?9.55
EPS?-$1.78
Dividend?0.00%
Ex-Dividend?N/A

Shares of Protagonist Therapeutics, Inc (PTGX) are trading at $97.38. The technical outlook is "Sell" and the fundamental picture shows "Neutral". Notable factors include a robust Altman Z-Score, negative Return on Equity and a bullish Golden Cross on the moving averages. Valuation-wise, the stock is priced at a premium — multiples like P/E and EV/EBITDA sit above sector averages.

Technical & fundamental data as of Jun 5, 2026.

News
Profile
Protagonist Therapeutics Inc is a biopharmaceutical company engaged in the discovery and development of peptide-based therapeutics using its proprietary technology platform. The company focuses on three therapeutic areas: inflammation and immunology, hematology, and metabolic diseases. Its pipeline includes clinical-stage and preclinical candidates such as rusfertide for polycythemia vera, icotrokinra for inflammatory diseases, and other programs targeting IL-17, obesity, and iron metabolism disorders, developed through internal research and strategic collaborations.
Themes
Biotech - Drug Development›Metabolic & CardiometabolicBiotech - Drug Development›Immunology & Autoimmune
Employees
131
Market Cap
6.3B
Industry
PHARMACEUTICAL PREPARATIONS
Website
www.protagonist-inc.com
Listed
2016-08-11
Address
7707 GATEWAY BLVD., SUITE 140
NEWARK, CA 94560-1160
Phone: (510) 474-0170
Technical OutlookSell
Strong SellNeutralStrong Buy
Long-Term (Tide)?▼ Bearish(-1/3)
Medium-Term (Wave)?▼ Bearish(-1/3)
Short-Term (Ripple)?▼ Bearish(-1/3)
MA Alignment?Mixed
Full Technical Analysis →
Fundamental OutlookNeutral
Strong SellNeutralStrong Buy
F-Score?
40
Z-Score?
100
Momentum?
23
Short Sent.?
48
Piotroski F-Score?4/9Mixed
Altman Z-Score?88.99Safe
Confidence?57%Low
Full Fundamental Analysis →
Short InterestVery High
Short % of Float?12.22%High
Short Interest?7.3M
Days to Cover?12.8
Free Float59.7M
Avg Daily Volume571.8K
Settlement Date2026-05-15
Financial Health
Current Ratio?17.76Strong
Quick Ratio?17.76Strong
Cash Ratio?5.61Strong
Debt/Equity?0.00Low
ValuationRICHLY VALUEDvs 1 peers + S&P 500
Score
50/100
P/E?
N/A▾
P/B?
Peers
100
S&P
20
9.55HIGH▾
P/S?
Peers
100
S&P
3
84.56HIGH▾
P/FCF?
N/A▾
EV/EBITDA?
S&P
97
-43.0CHEAP▾
EV/Sales?
Peers
100
S&P
3
81.94HIGH▾
Returns & Efficiency
ROE?
S&P
8
-17.5%WEAK▾
ROA?
S&P
3
-16.5%WEAK▾
Cash Flow & Enterprise
FCF?$-117895000
Enterprise Value?$6.1B
Fundamentals ratios updated end of day
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