XBI ETF — Holdings & Market Internals
A visuals-first look inside State Street SPDR S&P Biotech ETF (XBI): a weight-sized holdings treemap, sector concentration, and the breadth oscillators that reveal whether the fund's move is broad or narrow — built on the live 157-name holdings snapshot.
Historical breadth is computed against the current XBI membership, so older values carry a degree of survivorship bias (constituents removed from the fund are excluded from past readings).
Holdings Treemap
Tile size = ETF weight, grouped by sector. Color by:
Sector Weights
Share of the fund by GICS-style sector.
Market Breadth Snapshot
How many constituents are participating in the trend. See the full internals →
Trend Alignment
Cap-weighted share of the fund by where price sits across its 20/50/200-day SMAs — 26% is in full alignment.
Valuation & Fundamentals
Sector multiples and dispersion across holdings (cap-weighted harmonic mean). Full valuation →
Valuation by Sector & Distribution
Fund P/E: 23.1 — cap-weighted harmonic mean. Green = cheaper than the fund.
By sector (cap-weighted)
Distribution across holdings
One-Month Leaders
Strongest constituents over the trailing month.
One-Month Laggards
Weakest constituents — candidates for the opportunity scan.
| CMPX | Compass Therapeutics, Inc. Common Stock | 0.04% | -34.96% | 22 |
| NKTR | Nektar Therapeutics | 0.38% | -35.86% | 29 |
| BBOT | BridgeBio Oncology Therapeutics, Inc. Common Stock | 0.02% | -35.90% | 20 |
| FTH | Faeth Therapeutics, Inc. Common Stock | 0.04% | -44.99% | 27 |
| QURE | uniQure N.V. | 0.47% | -47.12% | 28 |
| AVTX | Avalo Therapeutics, Inc. Common Stock | 0.11% | -54.53% | 17 |
Holdings Explorer
Top 30 by weight — sort any column. View all 157 holdings →
| MRNA | Moderna, Inc. Common Stock | Health Care | 2.23% | $201.33 | -1.24% | +10.80% | +265.48% | 50 | 100 | $75.9B |
| NTRA | Natera, Inc. Common Stock | Health Care | 1.81% | $405.96 | +0.67% | +3.44% | +53.11% | 57 | 98 | $59.1B |
| BIIB | Biogen Inc. Common Stock | Health Care | 1.80% | $251.12 | -1.18% | +10.53% | +23.64% | 71 | 96 | $32.5B |
| HALO | Halozyme Therapeutics, Inc. | Health Care | 1.73% | $125.64 | +0.86% | +12.04% | +52.45% | 74 | 97 | $12.5B |
| UTHR | United Therapeutics Corp | Health Care | 1.72% | $592.41 | +0.45% | +24.28% | +10.91% | 69 | 92 | $23.2B |
| AMGN | Amgen Inc | Health Care | 1.71% | $442.00 | -1.81% | +8.17% | +16.04% | 61 | 93 | $217.9B |
| ABBV | ABBVIE INC. | Health Care | 1.70% | $285.27 | +0.16% | +7.64% | +10.29% | 65 | 86 | $464.4B |
| EXEL | Exelixis Inc | Health Care | 1.67% | $63.63 | -1.18% | +13.81% | +15.62% | 71 | 97 | $14.5B |
| GILD | Gilead Sciences Inc | Health Care | 1.61% | $156.99 | -0.72% | +3.27% | +19.11% | 58 | 87 | $179.5B |
| TWST | Twist Bioscience Corporation Common Stock | Health Care | 1.61% | $138.77 | +3.25% | -11.29% | +49.65% | 44 | 100 | $12.5B |
| IOVA | Iovance Biotherapeutics, Inc. Common Stock | Health Care | 1.61% | $14.07 | -0.46% | +35.48% | +180.68% | 59 | 100 | $6.4B |
| SYRE | Spyre Therapeutics, Inc. Common Stock | Health Care | 1.59% | $90.28 | -2.17% | +3.28% | -11.45% | 54 | 100 | $8.2B |
| VRTX | Vertex Pharmaceuticals Inc | Health Care | 1.53% | $524.88 | -2.10% | +1.62% | +9.32% | 55 | 86 | $127.9B |
| REGN | Regeneron Pharmaceuticals Inc | Health Care | 1.51% | $805.50 | -1.68% | +0.43% | +21.65% | 58 | 92 | $75.7B |
| ALKS | Alkermes Inc. plc | Health Care | 1.45% | $43.60 | -1.31% | +2.54% | -17.48% | 54 | 93 | $7.0B |
| TGTX | TG Therapeutics, Inc. | Health Care | 1.45% | $54.38 | +1.82% | -3.18% | -5.46% | 49 | 95 | $8.3B |
| PTGX | Protagonist Therapeutics, Inc | Health Care | 1.43% | $139.35 | -0.77% | -0.24% | +1.70% | 48 | 97 | $9.1B |
| PTCT | PTC Therapeutics, Inc. | Health Care | 1.39% | $60.60 | -3.93% | -2.64% | -21.94% | 41 | 45 | $5.3B |
| INCY | Incyte Genomics Inc | Health Care | 1.39% | $115.69 | -1.02% | -7.28% | -1.67% | 48 | 90 | $23.4B |
| NBIX | Neurocrine Biosciences Inc | Health Care | 1.38% | $140.60 | -0.44% | +3.00% | -19.13% | 50 | 58 | $14.6B |
| KRYS | Krystal Biotech, Inc. Common Stock | Health Care | 1.37% | $314.55 | -2.74% | -8.88% | -8.11% | 38 | 96 | $9.5B |
| CRSP | CRISPR Therapeutics AG | Health Care | 1.37% | $49.30 | -1.18% | -10.12% | +3.63% | 40 | 34 | $5.4B |
| RVMD | Revolution Medicines, Inc. Common Stock | Health Care | 1.35% | $185.93 | -0.34% | -1.66% | -1.02% | 44 | 100 | $44.3B |
| ROIV | Roivant Sciences Ltd. Common Shares | Health Care | 1.34% | $36.63 | -2.56% | -0.41% | +3.87% | 53 | 98 | $25.8B |
| BBIO | BridgeBio Pharma, Inc. Common Stock | Health Care | 1.34% | $68.57 | +0.59% | +4.12% | -18.48% | 52 | 87 | $13.1B |
| ORKA | Oruka Therapeutics, Inc. Common Stock | Health Care | 1.32% | $80.28 | -1.24% | -9.77% | -12.60% | 46 | 99 | $5.6B |
| ALNY | Alnylam Pharmaceuticals, Inc. | Health Care | 1.31% | $226.08 | -1.47% | -9.12% | -17.84% | 42 | 28 | $29.4B |
| BMRN | BioMarin Pharmaceuticals Inc | Health Care | 1.31% | $55.95 | -1.13% | -10.06% | -6.58% | 42 | 63 | $11.1B |
| PCVX | Vaxcyte, Inc. Common Stock | Health Care | 1.26% | $60.45 | -3.96% | +8.18% | +10.33% | 45 | 92 | $8.4B |
| GRAL | GRAIL, Inc. Common Stock | Health Care | 1.26% | $133.30 | +4.31% | +25.64% | +83.82% | 57 | 93 | $6.4B |