XBI ETF — Holdings & Market Internals
A visuals-first look inside State Street SPDR S&P Biotech ETF (XBI): a weight-sized holdings treemap, sector concentration, and the breadth oscillators that reveal whether the fund's move is broad or narrow — built on the live 147-name holdings snapshot.
Historical breadth is computed against the current XBI membership, so older values carry a degree of survivorship bias (constituents removed from the fund are excluded from past readings).
Holdings Treemap
Tile size = ETF weight, grouped by sector. Color by:
Sector Weights
Share of the fund by GICS-style sector.
Market Breadth Snapshot
How many constituents are participating in the trend. See the full internals →
Trend Alignment
Cap-weighted share of the fund by where price sits across its 20/50/200-day SMAs — 67% is in full alignment.
Valuation & Fundamentals
Sector multiples and dispersion across holdings (cap-weighted harmonic mean). Full valuation →
Valuation by Sector & Distribution
Fund P/E: 20.1 — cap-weighted harmonic mean. Green = cheaper than the fund.
By sector (cap-weighted)
Distribution across holdings
One-Month Leaders
Strongest constituents over the trailing month.
| MRNA | Moderna, Inc. Common Stock | 2.65% | +190.10% | 73 |
| PURR | Hyperliquid Strategies Inc Common Stock | 0.59% | +86.64% | 84 |
| IOVA | Iovance Biotherapeutics, Inc. Common Stock | 1.20% | +68.13% | 71 |
| IMMX | Immix Biopharma, Inc. Common Stock | 0.26% | +67.67% | 77 |
| TWST | Twist Bioscience Corporation Common Stock | 1.84% | +61.95% | 70 |
| FDMT | 4D Molecular Therapeutics, Inc. Common Stock | 0.24% | +53.82% | 71 |
One-Month Laggards
Weakest constituents — candidates for the opportunity scan.
Holdings Explorer
Top 30 by weight — sort any column. View all 147 holdings →
| MRNA | Moderna, Inc. Common Stock | Health Care | 2.65% | $158.79 | +14.35% | +190.10% | +236.43% | 73 | 100 | $22.0B |
| TWST | Twist Bioscience Corporation Common Stock | Health Care | 1.84% | $151.55 | +7.69% | +61.95% | +148.07% | 70 | 100 | $6.3B |
| ORKA | Oruka Therapeutics, Inc. Common Stock | Health Care | 1.50% | $101.67 | -0.54% | +11.04% | +65.00% | 52 | 100 | $5.7B |
| APGE | Apogee Therapeutics, Inc. Common Stock | Health Care | 1.49% | $134.88 | +0.04% | +0.42% | +63.97% | 78 | 99 | $10.1B |
| KYMR | Kymera Therapeutics, Inc. Common Stock | Health Care | 1.42% | $126.72 | +4.67% | +14.53% | +59.96% | 67 | 98 | $8.5B |
| PRAX | Praxis Precision Medicines, Inc. Common Stock | Health Care | 1.39% | $365.63 | -0.01% | +13.13% | +6.98% | 57 | 100 | $8.5B |
| HALO | Halozyme Therapeutics, Inc. | Health Care | 1.38% | $109.31 | +0.65% | +32.65% | +58.53% | 79 | 90 | $9.8B |
| NTRA | Natera, Inc. Common Stock | Health Care | 1.37% | $339.50 | +2.74% | +27.62% | +63.87% | 72 | 96 | $38.7B |
| RVMD | Revolution Medicines, Inc. Common Stock | Health Care | 1.34% | $210.95 | -0.17% | +11.89% | +38.05% | 64 | 100 | $38.8B |
| SYRE | Spyre Therapeutics, Inc. Common Stock | Health Care | 1.31% | $95.29 | -12.80% | +5.24% | +43.40% | 59 | 100 | $8.2B |
| DNTH | Dianthus Therapeutics, Inc. Common Stock | Health Care | 1.31% | $111.98 | +1.84% | +7.96% | +28.07% | 55 | 99 | $5.8B |
| PTGX | Protagonist Therapeutics, Inc | Health Care | 1.30% | $149.50 | -2.71% | +10.64% | +50.54% | 57 | 98 | $8.5B |
| CGON | CG Oncology, Inc. Common stock | Health Care | 1.29% | $78.61 | +0.95% | +12.69% | +23.36% | 59 | 98 | $6.3B |
| TVTX | Travere Therapeutics, Inc. Common Stock | Health Care | 1.26% | $67.24 | +2.88% | +15.63% | +50.82% | 69 | 99 | $5.1B |
| REGN | Regeneron Pharmaceuticals Inc | Health Care | 1.26% | $833.61 | +0.66% | +25.96% | +29.75% | 74 | 86 | $78.2B |
| INSM | Insmed, Inc. | Health Care | 1.25% | $124.09 | -0.10% | +15.86% | +14.90% | 56 | 41 | $21.4B |
| PCVX | Vaxcyte, Inc. Common Stock | Health Care | 1.24% | $61.12 | -1.13% | +11.54% | +27.96% | 58 | 95 | $7.7B |
| IOVA | Iovance Biotherapeutics, Inc. Common Stock | Health Care | 1.20% | $8.43 | +4.78% | +68.13% | +107.12% | 71 | 99 | $1.8B |
| ROIV | Roivant Sciences Ltd. Common Shares | Health Care | 1.19% | $36.48 | +0.36% | +3.81% | +21.65% | 57 | 99 | $24.1B |
| ERAS | Erasca, Inc. Common Stock | Health Care | 1.17% | $17.77 | +0.94% | -6.67% | +56.34% | 48 | 100 | $6.3B |
| AMGN | Amgen Inc | Health Care | 1.17% | $441.95 | -0.36% | +16.82% | +29.86% | 73 | 90 | $207.9B |
| RYTM | Rhythm Pharmaceuticals, Inc. Common Stock | Health Care | 1.16% | $112.95 | +1.71% | +8.32% | +27.66% | 55 | 62 | $7.1B |
| SRRK | Scholar Rock Holding Corporation Common Stock | Health Care | 1.15% | $58.92 | +0.11% | +19.78% | +21.03% | 66 | 93 | $5.5B |
| RLAY | Relay Therapeutics, Inc. Common Stock | Health Care | 1.14% | $19.89 | +4.15% | +11.37% | +47.88% | 60 | 100 | $4.1B |
| VRTX | Vertex Pharmaceuticals Inc | Health Care | 1.13% | $554.68 | +1.00% | +15.35% | +26.22% | 68 | 86 | $119.5B |
| VKTX | Viking Therapeutics, Inc | Health Care | 1.13% | $34.25 | +2.83% | -3.50% | +10.51% | 50 | 85 | $3.8B |
| ARWR | Arrowhead Research Corporation | Health Care | 1.13% | $88.86 | +2.43% | +3.63% | +18.40% | 57 | 99 | $11.9B |
| BBIO | BridgeBio Pharma, Inc. Common Stock | Health Care | 1.13% | $80.34 | -0.80% | -4.41% | +17.39% | 47 | 91 | $15.7B |
| INCY | Incyte Genomics Inc | Health Care | 1.11% | $130.24 | +1.37% | +10.24% | +33.25% | 68 | 89 | $24.2B |
| BMRN | BioMarin Pharmaceuticals Inc | Health Care | 1.10% | $66.11 | +1.58% | +10.40% | +21.99% | 56 | 65 | $11.6B |