XBI ETF — Holdings & Market Internals
A visuals-first look inside State Street SPDR S&P Biotech ETF (XBI): a weight-sized holdings treemap, sector concentration, and the breadth oscillators that reveal whether the fund's move is broad or narrow — built on the live 157-name holdings snapshot.
Historical breadth is computed against the current XBI membership, so older values carry a degree of survivorship bias (constituents removed from the fund are excluded from past readings).
Holdings Treemap
Tile size = ETF weight, grouped by sector. Color by:
Sector Weights
Share of the fund by GICS-style sector.
Market Breadth Snapshot
How many constituents are participating in the trend. See the full internals →
Trend Alignment
Cap-weighted share of the fund by where price sits across its 20/50/200-day SMAs — 28% is in full alignment.
Valuation & Fundamentals
Sector multiples and dispersion across holdings (cap-weighted harmonic mean). Full valuation →
Valuation by Sector & Distribution
Fund P/E: 22.6 — cap-weighted harmonic mean. Green = cheaper than the fund.
By sector (cap-weighted)
Distribution across holdings
One-Month Leaders
Strongest constituents over the trailing month.
One-Month Laggards
Weakest constituents — candidates for the opportunity scan.
Holdings Explorer
Top 30 by weight — sort any column. View all 157 holdings →
| TWST | Twist Bioscience Corporation Common Stock | Health Care | 2.20% | $204.60 | +8.18% | +43.55% | +94.91% | 71 | 100 | $8.5B |
| MRNA | Moderna, Inc. Common Stock | Health Care | 2.04% | $204.38 | +7.70% | +25.50% | +141.90% | 66 | 100 | $59.4B |
| NTRA | Natera, Inc. Common Stock | Health Care | 1.81% | $420.28 | +2.16% | +28.83% | +47.87% | 78 | 99 | $47.2B |
| UTHR | United Therapeutics Corp | Health Care | 1.65% | $544.53 | +0.52% | +6.22% | -2.63% | 60 | 87 | $21.0B |
| IOVA | Iovance Biotherapeutics, Inc. Common Stock | Health Care | 1.59% | $14.31 | +0.49% | +71.06% | +230.58% | 80 | 100 | $3.9B |
| BIIB | Biogen Inc. Common Stock | Health Care | 1.55% | $220.76 | +0.49% | +0.77% | +1.82% | 49 | 94 | $32.9B |
| AMGN | Amgen Inc | Health Care | 1.53% | $402.80 | -0.07% | -8.54% | +8.43% | 48 | 91 | $239.4B |
| ABBV | ABBVIE INC. | Health Care | 1.52% | $263.55 | +0.29% | +0.05% | +1.12% | 54 | 73 | $462.5B |
| SYRE | Spyre Therapeutics, Inc. Common Stock | Health Care | 1.52% | $91.86 | -1.11% | +5.84% | +6.78% | 54 | 100 | $7.7B |
| CRSP | CRISPR Therapeutics AG | Health Care | 1.49% | $56.02 | +0.47% | -2.98% | -6.65% | 51 | 41 | $5.5B |
| GILD | Gilead Sciences Inc | Health Care | 1.48% | $144.20 | -0.51% | -3.51% | +8.93% | 44 | 87 | $185.5B |
| HALO | Halozyme Therapeutics, Inc. | Health Care | 1.46% | $108.59 | -1.38% | +3.80% | +38.76% | 53 | 92 | $12.4B |
| EXEL | Exelixis Inc | Health Care | 1.46% | $59.23 | +1.34% | +2.06% | +4.43% | 56 | 91 | $14.5B |
| RVMD | Revolution Medicines, Inc. Common Stock | Health Care | 1.45% | $208.41 | +1.32% | -2.23% | +7.49% | 56 | 100 | $45.2B |
| TGTX | TG Therapeutics, Inc. | Health Care | 1.44% | $53.59 | -0.61% | -3.36% | +1.67% | 46 | 93 | $8.7B |
| VRTX | Vertex Pharmaceuticals Inc | Health Care | 1.42% | $501.93 | -0.46% | -8.63% | -4.16% | 39 | 87 | $141.4B |
| PTGX | Protagonist Therapeutics, Inc | Health Care | 1.40% | $141.06 | +1.25% | -5.36% | +6.71% | 44 | 98 | $9.6B |
| PTCT | PTC Therapeutics, Inc. | Health Care | 1.39% | $63.62 | +0.60% | -10.81% | -24.57% | 38 | 62 | $6.0B |
| KRYS | Krystal Biotech, Inc. Common Stock | Health Care | 1.37% | $335.29 | +3.61% | -11.95% | -13.75% | 37 | 96 | $10.9B |
| INCY | Incyte Genomics Inc | Health Care | 1.36% | $113.62 | -1.20% | -8.80% | -0.92% | 34 | 89 | $26.1B |
| MDGL | Madrigal Pharmaceuticals, Inc. Common Stock | Health Care | 1.34% | $493.88 | -1.43% | -8.12% | -4.64% | 37 | 70 | $12.5B |
| ORKA | Oruka Therapeutics, Inc. Common Stock | Health Care | 1.34% | $83.66 | -1.00% | -9.17% | +1.00% | 38 | 100 | $6.0B |
| REGN | Regeneron Pharmaceuticals Inc | Health Care | 1.33% | $730.92 | -0.79% | -11.02% | +11.74% | 35 | 87 | $86.8B |
| BMRN | BioMarin Pharmaceuticals Inc | Health Care | 1.33% | $57.55 | +0.85% | -12.03% | -2.62% | 27 | 63 | $13.0B |
| NBIX | Neurocrine Biosciences Inc | Health Care | 1.33% | $146.51 | +2.16% | -9.03% | -18.19% | 41 | 60 | $16.1B |
| ALNY | Alnylam Pharmaceuticals, Inc. | Health Care | 1.31% | $219.94 | -0.20% | -10.86% | -31.20% | 34 | 27 | $35.8B |
| ALKS | Alkermes Inc. plc | Health Care | 1.31% | $43.05 | +2.71% | -12.47% | -22.73% | 37 | 90 | $8.0B |
| CYTK | Cytokinetics Inc. | Health Care | 1.30% | $62.91 | -3.87% | -8.76% | -23.76% | 33 | 81 | $10.0B |
| BBIO | BridgeBio Pharma, Inc. Common Stock | Health Care | 1.29% | $66.20 | -1.23% | -12.21% | -13.20% | 38 | 87 | $15.0B |
| GRAL | GRAIL, Inc. Common Stock | Health Care | 1.29% | $154.50 | +7.15% | +81.34% | +107.65% | 82 | 98 | $3.6B |