XBI ETF — Holdings & Market Internals
A visuals-first look inside State Street SPDR S&P Biotech ETF (XBI): a weight-sized holdings treemap, sector concentration, and the breadth oscillators that reveal whether the fund's move is broad or narrow — built on the live 146-name holdings snapshot.
Historical breadth is computed against the current XBI membership, so older values carry a degree of survivorship bias (constituents removed from the fund are excluded from past readings).
Holdings Treemap
Tile size = ETF weight, grouped by sector. Color by:
Sector Weights
Share of the fund by GICS-style sector.
Market Breadth Snapshot
How many constituents are participating in the trend. See the full internals →
Trend Alignment
Cap-weighted share of the fund by where price sits across its 20/50/200-day SMAs — 23% is in full alignment.
Valuation & Fundamentals
Sector multiples and dispersion across holdings (cap-weighted harmonic mean). Full valuation →
Valuation by Sector & Distribution
Fund P/E: 19.5 — cap-weighted harmonic mean. Green = cheaper than the fund.
By sector (cap-weighted)
Distribution across holdings
One-Month Leaders
Strongest constituents over the trailing month.
| MRNA | Moderna, Inc. Common Stock | 2.87% | +129.92% | 62 |
| CAPR | Capricor Therapeutics Inc | 0.18% | +110.77% | 47 |
| PURR | Hyperliquid Strategies Inc Common Stock | 0.68% | +74.78% | 60 |
| EBS | Emergent Biosolutions, Inc. | 0.10% | +41.15% | 57 |
| IOVA | Iovance Biotherapeutics, Inc. Common Stock | 1.15% | +37.39% | 69 |
| SION | Sionna Therapeutics, Inc. Common Stock | 0.05% | +31.32% | 33 |
One-Month Laggards
Weakest constituents — candidates for the opportunity scan.
| OCGN | Ocugen, Inc. Common Stock | 0.14% | -24.82% | 32 |
| SPRY | ARS Pharmaceuticals, Inc. Common Stock | 0.11% | -25.99% | 28 |
| ANNX | Annexon, Inc. Common Stock | 0.25% | -26.31% | 26 |
| DYN | Dyne Therapeutics, Inc. Common Stock | 0.74% | -28.77% | 21 |
| BBOT | BridgeBio Oncology Therapeutics, Inc. Common Stock | 0.04% | -46.73% | 18 |
| RARE | Ultragenyx Pharmaceutical Inc. | 0.51% | -49.72% | 19 |
Holdings Explorer
Top 30 by weight — sort any column. View all 146 holdings →
| MRNA | Moderna, Inc. Common Stock | Health Care | 2.87% | $146.82 | +1.89% | +129.92% | +193.50% | 62 | 100 | $59.4B |
| TWST | Twist Bioscience Corporation Common Stock | Health Care | 1.81% | $134.56 | +5.91% | +6.76% | +79.62% | 56 | 100 | $8.5B |
| HALO | Halozyme Therapeutics, Inc. | Health Care | 1.47% | $107.94 | +0.66% | +5.88% | +52.01% | 64 | 90 | $12.4B |
| NTRA | Natera, Inc. Common Stock | Health Care | 1.46% | $342.63 | +4.00% | +7.59% | +52.78% | 67 | 97 | $47.2B |
| KYMR | Kymera Therapeutics, Inc. Common Stock | Health Care | 1.44% | $114.63 | -0.31% | -0.09% | +38.89% | 47 | 98 | $9.9B |
| TVTX | Travere Therapeutics, Inc. Common Stock | Health Care | 1.40% | $66.43 | -0.55% | +3.89% | +33.99% | 56 | 98 | $6.3B |
| ROIV | Roivant Sciences Ltd. Common Shares | Health Care | 1.39% | $40.65 | +0.45% | +11.77% | +36.73% | 68 | 99 | $24.9B |
| ORKA | Oruka Therapeutics, Inc. Common Stock | Health Care | 1.38% | $95.93 | +3.85% | -11.52% | +40.41% | 50 | 100 | $6.0B |
| RVMD | Revolution Medicines, Inc. Common Stock | Health Care | 1.36% | $206.05 | +0.62% | -0.84% | +36.38% | 50 | 100 | $45.2B |
| PRAX | Praxis Precision Medicines, Inc. Common Stock | Health Care | 1.36% | $332.94 | -1.23% | -14.81% | +33.69% | 41 | 100 | $9.9B |
| INSM | Insmed, Inc. | Health Care | 1.34% | $125.81 | -3.14% | -5.43% | +31.73% | 53 | 39 | $27.7B |
| PTGX | Protagonist Therapeutics, Inc | Health Care | 1.33% | $147.71 | -0.38% | -3.51% | +34.53% | 53 | 98 | $9.6B |
| DNTH | Dianthus Therapeutics, Inc. Common Stock | Health Care | 1.31% | $107.67 | +1.38% | -4.67% | +39.06% | 50 | 99 | $5.9B |
| REGN | Regeneron Pharmaceuticals Inc | Health Care | 1.27% | $790.72 | +1.54% | -1.06% | +29.46% | 50 | 90 | $86.8B |
| CGON | CG Oncology, Inc. Common stock | Health Care | 1.27% | $74.18 | +1.97% | -4.48% | +27.14% | 48 | 98 | $6.6B |
| PCVX | Vaxcyte, Inc. Common Stock | Health Care | 1.25% | $59.48 | +0.15% | -0.77% | +25.88% | 50 | 96 | $9.1B |
| SMMT | Summit Therapeutics Inc. Common Stock | Health Care | 1.23% | $18.64 | +4.96% | +21.50% | +41.69% | 71 | 58 | $13.7B |
| SRRK | Scholar Rock Holding Corporation Common Stock | Health Care | 1.22% | $51.05 | -6.44% | -5.45% | +15.97% | 41 | 94 | $6.8B |
| ERAS | Erasca, Inc. Common Stock | Health Care | 1.16% | $16.43 | +1.73% | -14.77% | +14.20% | 41 | 100 | $5.7B |
| RLAY | Relay Therapeutics, Inc. Common Stock | Health Care | 1.16% | $19.07 | +1.01% | -6.25% | +34.13% | 49 | 100 | $4.2B |
| RYTM | Rhythm Pharmaceuticals, Inc. Common Stock | Health Care | 1.15% | $102.40 | -2.16% | -13.32% | +16.87% | 41 | 57 | $7.2B |
| GILD | Gilead Sciences Inc | Health Care | 1.15% | $147.37 | +1.88% | +6.92% | +16.08% | 56 | 84 | $185.5B |
| TGTX | TG Therapeutics, Inc. | Health Care | 1.15% | $54.36 | +0.16% | +8.65% | +12.38% | 50 | 95 | $8.7B |
| IOVA | Iovance Biotherapeutics, Inc. Common Stock | Health Care | 1.15% | $9.23 | +7.79% | +37.39% | +134.43% | 69 | 99 | $3.9B |
| SYRE | Spyre Therapeutics, Inc. Common Stock | Health Care | 1.14% | $90.75 | +0.22% | -10.10% | +11.97% | 43 | 100 | $7.7B |
| VRTX | Vertex Pharmaceuticals Inc | Health Care | 1.14% | $521.04 | +0.80% | -1.73% | +18.07% | 46 | 87 | $141.4B |
| SLS | SELLAS Life Sciences Group, Inc. Common Stock | Health Care | 1.13% | $11.73 | +1.56% | +0.21% | +52.83% | 42 | 100 | $2.8B |
| ARWR | Arrowhead Research Corporation | Health Care | 1.13% | $80.70 | -2.66% | -7.91% | +8.24% | 39 | 99 | $12.1B |
| INCY | Incyte Genomics Inc | Health Care | 1.13% | $121.95 | +0.55% | -0.03% | +13.32% | 46 | 90 | $26.1B |
| BMRN | BioMarin Pharmaceuticals Inc | Health Care | 1.13% | $66.42 | +1.13% | -5.60% | +19.57% | 56 | 81 | $13.0B |