State Street SPDR S&P Biotech ETF

XBI Holdings

The complete, up-to-date list of XBI ETF holdings. XBI holds 157 stocks weighted by market capitalization. Below are all constituents with their ETF weight, sector, price, and recent performance.

Live · 157 quotesAs of October 3, 2026157 holdings

Top 10 XBI Holdings

The 10 largest positions make up about 16.9% of the fund. Because XBI is market-cap weighted, these largest constituents drive most of its day-to-day movement.

TWSTTwist Bioscience Corporation Common StockWeight2.20%Price$205.721M+43.55%
MRNAModerna, Inc. Common StockWeight2.04%Price$205.391M+25.50%
NTRANatera, Inc. Common StockWeight1.81%Price$421.021M+28.83%
UTHRUnited Therapeutics CorpWeight1.65%Price$543.701M+6.22%
IOVAIovance Biotherapeutics, Inc. Common StockWeight1.59%Price$14.381M+71.06%
BIIBBiogen Inc. Common StockWeight1.55%Price$220.981M+0.77%
AMGNAmgen IncWeight1.53%Price$402.951M-8.54%
ABBVABBVIE INC.Weight1.52%Price$263.801M+0.05%
SYRESpyre Therapeutics, Inc. Common StockWeight1.52%Price$92.141M+5.84%
CRSPCRISPR Therapeutics AGWeight1.49%Price$56.171M-2.98%

XBI Sector Weights

How State Street SPDR S&P Biotech ETF is allocated across sectors.

Health Care

99.1%156

Finance

0.7%1

Complete XBI Holdings List — All Stocks in XBI by Weight

Every stock in XBI — all 157 constituents — ranked by ETF weight, with price, recent performance, and RSI. Select any ticker for its full quote, chart, and analysis.

#
1	TWST	Twist Bioscience Corporation Common Stock	Health Care	2.20%	$205.72	+8.29%	+43.55%	+94.91%	71	100	$8.5B
2	MRNA	Moderna, Inc. Common Stock	Health Care	2.04%	$205.39	+7.78%	+25.50%	+141.90%	66	100	$59.4B
3	NTRA	Natera, Inc. Common Stock	Health Care	1.81%	$421.02	+2.42%	+28.83%	+47.87%	78	99	$47.2B
4	UTHR	United Therapeutics Corp	Health Care	1.65%	$543.70	+0.65%	+6.22%	-2.63%	60	87	$21.0B
5	IOVA	Iovance Biotherapeutics, Inc. Common Stock	Health Care	1.59%	$14.38	+0.67%	+71.06%	+230.58%	80	100	$3.9B
6	BIIB	Biogen Inc. Common Stock	Health Care	1.55%	$220.98	+0.35%	+0.77%	+1.82%	49	94	$32.9B
7	AMGN	Amgen Inc	Health Care	1.53%	$402.95	-0.12%	-8.54%	+8.43%	48	91	$239.4B
8	ABBV	ABBVIE INC.	Health Care	1.52%	$263.80	+0.31%	+0.05%	+1.12%	54	73	$462.5B
9	SYRE	Spyre Therapeutics, Inc. Common Stock	Health Care	1.52%	$92.14	-1.11%	+5.84%	+6.78%	54	100	$7.7B
10	CRSP	CRISPR Therapeutics AG	Health Care	1.49%	$56.17	+0.47%	-2.98%	-6.65%	51	41	$5.5B
11	GILD	Gilead Sciences Inc	Health Care	1.48%	$144.28	-0.53%	-3.51%	+8.93%	44	87	$185.5B
12	HALO	Halozyme Therapeutics, Inc.	Health Care	1.46%	$108.79	-1.45%	+3.80%	+38.76%	53	92	$12.4B
13	EXEL	Exelixis Inc	Health Care	1.46%	$59.36	+1.42%	+2.06%	+4.43%	56	91	$14.5B
14	RVMD	Revolution Medicines, Inc. Common Stock	Health Care	1.45%	$208.63	+1.28%	-2.23%	+7.49%	56	100	$45.2B
15	TGTX	TG Therapeutics, Inc.	Health Care	1.44%	$53.60	-0.76%	-3.36%	+1.67%	46	93	$8.7B
16	VRTX	Vertex Pharmaceuticals Inc	Health Care	1.42%	$502.53	-0.48%	-8.63%	-4.16%	39	87	$141.4B
17	PTGX	Protagonist Therapeutics, Inc	Health Care	1.40%	$141.06	+1.25%	-5.36%	+6.71%	44	98	$9.6B
18	PTCT	PTC Therapeutics, Inc.	Health Care	1.39%	$63.78	+0.33%	-10.81%	-24.57%	38	62	$6.0B
19	KRYS	Krystal Biotech, Inc. Common Stock	Health Care	1.37%	$336.07	+3.51%	-11.95%	-13.75%	37	96	$10.9B
20	INCY	Incyte Genomics Inc	Health Care	1.36%	$113.68	-1.20%	-8.80%	-0.92%	34	89	$26.1B
21	MDGL	Madrigal Pharmaceuticals, Inc. Common Stock	Health Care	1.34%	$494.12	-1.43%	-8.12%	-4.64%	37	70	$12.5B
22	ORKA	Oruka Therapeutics, Inc. Common Stock	Health Care	1.34%	$83.89	-0.75%	-9.17%	+1.00%	38	100	$6.0B
23	REGN	Regeneron Pharmaceuticals Inc	Health Care	1.33%	$730.35	-0.82%	-11.02%	+11.74%	35	87	$86.8B
24	BMRN	BioMarin Pharmaceuticals Inc	Health Care	1.33%	$57.61	+0.73%	-12.03%	-2.62%	27	63	$13.0B
25	NBIX	Neurocrine Biosciences Inc	Health Care	1.33%	$146.57	+2.19%	-9.03%	-18.19%	41	60	$16.1B
26	ALNY	Alnylam Pharmaceuticals, Inc.	Health Care	1.31%	$220.17	-0.26%	-10.86%	-31.20%	34	27	$35.8B
27	ALKS	Alkermes Inc. plc	Health Care	1.31%	$43.07	+2.95%	-12.47%	-22.73%	37	90	$8.0B
28	CYTK	Cytokinetics Inc.	Health Care	1.30%	$62.91	-4.02%	-8.76%	-23.76%	33	81	$10.0B
29	BBIO	BridgeBio Pharma, Inc. Common Stock	Health Care	1.29%	$66.52	-1.31%	-12.21%	-13.20%	38	87	$15.0B
30	GRAL	GRAIL, Inc. Common Stock	Health Care	1.29%	$154.70	+7.15%	+81.34%	+107.65%	82	98	$3.6B
31	TVTX	Travere Therapeutics, Inc. Common Stock	Health Care	1.26%	$57.66	+1.28%	-14.22%	+0.49%	35	98	$6.3B
32	KOD	Kodiak Sciences Inc Common Stock	Health Care	1.25%	$95.24	+0.77%	+152.27%	+144.69%	85	100	$2.4B
33	ROIV	Roivant Sciences Ltd. Common Shares	Health Care	1.24%	$36.15	+1.01%	+3.12%	+2.03%	42	98	$24.9B
34	INSM	Insmed, Inc.	Health Care	1.24%	$104.18	-6.61%	-8.25%	+0.47%	38	36	$27.7B
35	COGT	Cogent Biosciences, Inc. Common Stock	Health Care	1.22%	$30.84	-0.68%	-11.82%	-20.20%	35	98	$6.0B
36	PRAX	Praxis Precision Medicines, Inc. Common Stock	Health Care	1.22%	$283.42	-3.85%	-17.55%	-7.38%	40	100	$9.9B
37	ERAS	Erasca, Inc. Common Stock	Health Care	1.21%	$14.51	-1.29%	-13.14%	-20.19%	42	100	$5.7B
38	DNTH	Dianthus Therapeutics, Inc. Common Stock	Health Care	1.21%	$88.33	+0.23%	-18.09%	-6.45%	30	98	$5.9B
39	KYMR	Kymera Therapeutics, Inc. Common Stock	Health Care	1.17%	$107.23	-0.60%	-10.19%	-4.11%	37	97	$9.9B
40	IONS	Ionis Pharmaceuticals, Inc. Common Stock	Health Care	1.15%	$43.70	+0.07%	-27.73%	-46.97%	30	32	$10.2B
41	ARWR	Arrowhead Research Corporation	Health Care	1.15%	$63.00	-1.83%	-22.54%	-24.12%	30	96	$12.1B
42	PCVX	Vaxcyte, Inc. Common Stock	Health Care	1.11%	$73.18	+32.26%	-8.36%	-2.22%	43	94	$9.1B
43	RYTM	Rhythm Pharmaceuticals, Inc. Common Stock	Health Care	1.10%	$91.00	-2.65%	-12.01%	-18.21%	29	47	$7.2B
44	IBRX	ImmunityBio, Inc. Common Stock	Health Care	1.08%	$10.46	+1.51%	+29.45%	+10.59%	70	100	$8.4B
45	CGON	CG Oncology, Inc. Common stock	Health Care	1.04%	$67.83	+0.76%	-12.31%	-3.74%	39	95	$6.6B
46	VKTX	Viking Therapeutics, Inc	Health Care	1.04%	$29.29	-2.27%	-11.08%	-19.30%	42	75	$4.0B
47	MIRM	Mirum Pharmaceuticals, Inc. Common Stock	Health Care	1.02%	$82.15	-0.82%	-16.19%	-33.62%	26	74	$6.1B
48	VCYT	Veracyte, Inc.	Health Care	1.02%	$46.92	+2.51%	+5.29%	-18.25%	54	89	$3.6B
49	TNGX	Tango Therapeutics, Inc.	Health Care	0.99%	$22.95	-1.29%	+2.74%	-20.19%	45	99	$3.8B
50	CELC	Celcuity Inc. Common Stock	Health Care	0.89%	$73.78	+2.25%	-22.98%	-33.19%	30	92	$4.7B
51	RLAY	Relay Therapeutics, Inc. Common Stock	Health Care	0.89%	$19.12	+0.45%	+1.39%	+1.55%	53	99	$4.2B
52	CDNA	CareDx, Inc.	Health Care	0.87%	$69.98	+3.66%	+35.52%	+130.36%	81	100	$2.6B
53	SRRK	Scholar Rock Holding Corporation Common Stock	Health Care	0.83%	$43.70	-6.23%	-17.33%	-14.80%	38	85	$6.8B
54	BEAM	Beam Therapeutics Inc. Common Stock	Health Care	0.83%	$25.60	+2.61%	-16.30%	-29.64%	42	59	$3.0B
55	ARQT	Arcutis Biotherapeutics, Inc. Common Stock	Health Care	0.76%	$25.16	-0.40%	+5.05%	-2.63%	47	88	$3.0B
56	RARE	Ultragenyx Pharmaceutical Inc.	Health Care	0.75%	$14.81	-2.23%	-41.37%	-54.27%	39	28	$1.5B
57	PURR	Hyperliquid Strategies Inc Common Stock	Finance	0.71%	$12.85	+7.95%	+5.88%	+45.35%	50	0	$2.5B
58	IMVT	Immunovant, Inc. Common Stock	Health Care	0.70%	$33.51	-0.48%	-16.26%	-12.56%	29	97	$8.2B
59	DYN	Dyne Therapeutics, Inc. Common Stock	Health Care	0.68%	$15.40	+0.66%	-40.51%	-34.11%	21	82	$4.7B
60	RXRX	Recursion Pharmaceuticals, Inc. Class A Common Stock	Health Care	0.67%	$4.79	+14.56%	+23.35%	+8.99%	62	41	$1.8B
61	SLS	SELLAS Life Sciences Group, Inc. Common Stock	Health Care	0.64%	$11.64	-1.11%	-11.53%	-20.62%	47	100	$2.8B
62	DNLI	Denali Therapeutics Inc. Common Stock	Health Care	0.62%	$19.94	-0.53%	-14.27%	-22.45%	36	89	$3.7B
63	SMMT	Summit Therapeutics Inc. Common Stock	Health Care	0.60%	$17.39	+4.98%	+18.41%	+8.10%	54	38	$13.7B
64	IDYA	IDEAYA Biosciences, Inc. Common Stock	Health Care	0.59%	$38.24	+1.97%	-7.06%	-1.32%	45	90	$3.9B
65	VERA	Vera Therapeutics, Inc. Class A Common Stock	Health Care	0.56%	$29.35	-3.62%	-11.67%	-27.59%	38	62	$2.5B
66	BCRX	BioCryst Pharmaceuticals Inc	Health Care	0.55%	$8.15	-0.67%	-18.30%	-16.63%	36	68	$2.6B
67	AGIO	Agios Pharmaceuticals, Inc.	Health Care	0.55%	$31.29	-1.65%	-7.80%	-14.45%	40	38	$2.0B
68	ABSI	Absci Corporation Common Stock	Health Care	0.53%	$11.37	+1.99%	+24.38%	-4.82%	64	99	$1.5B
69	RCUS	Arcus Biosciences, Inc.	Health Care	0.52%	$24.90	+1.76%	-18.99%	-19.66%	37	96	$3.8B
70	SRPT	Sarepta Therapeutics,, Inc. Common Stock	Health Care	0.52%	$17.40	-0.57%	-17.96%	-8.90%	38	47	$2.4B
71	NTLA	Intellia Therapeutics, Inc	Health Care	0.52%	$12.67	+2.45%	-3.24%	-29.26%	51	34	$1.8B
72	CLDX	Celldex Therapeutics, Inc	Health Care	0.51%	$32.76	+3.40%	-19.73%	-17.15%	31	84	$3.1B
73	NRIX	Nurix Therapeutics, Inc. Common stock	Health Care	0.51%	$22.89	-0.74%	-12.75%	-3.24%	34	98	$2.6B
74	ACAD	Acadia Pharmaceuticals Inc.	Health Care	0.49%	$20.16	+0.60%	-31.44%	-22.67%	16	48	$5.0B
75	NVAX	Novavax Inc	Health Care	0.48%	$12.32	+17.02%	+1.80%	+10.11%	59	82	$1.7B
76	BHVN	Biohaven Ltd.	Health Care	0.48%	$13.10	+0.70%	-19.41%	-20.04%	43	41	$2.4B
77	PVLA	Palvella Therapeutics, Inc. Common Stock	Health Care	0.48%	$131.63	-1.68%	-13.85%	-9.80%	33	97	$2.2B
78	QURE	uniQure N.V.	Health Care	0.47%	$22.85	-3.15%	-53.75%	-43.89%	17	26	$3.1B
79	VRDN	Viridian Therapeutics, Inc. Common Stock	Health Care	0.47%	$19.10	-1.98%	-16.05%	+0.00%	36	44	$2.6B
80	PGEN	Precigen, Inc. Common Stock	Health Care	0.46%	$7.63	-10.66%	+23.59%	+53.05%	67	99	$2.6B
81	SNDX	Syndax Pharmaceuticals, Inc.	Health Care	0.46%	$17.73	+0.23%	-13.00%	-19.19%	41	74	$1.8B
82	NKTR	Nektar Therapeutics	Health Care	0.45%	$41.70	-4.33%	-39.79%	-37.79%	22	36	$2.6B
83	IRON	Disc Medicine, Inc. Common Stock	Health Care	0.45%	$63.71	-1.52%	-18.79%	-15.93%	30	54	$3.1B
84	ADMA	ADMA Biologics, Inc.	Health Care	0.45%	$10.11	+3.40%	+4.07%	+9.03%	53	32	$2.1B
85	VCEL	Vericel Corporation	Health Care	0.43%	$40.74	+1.10%	-0.84%	-13.90%	48	87	$2.1B
86	IMNM	Immunome, Inc.	Health Care	0.40%	$21.28	+1.56%	-24.17%	-11.06%	31	96	$3.1B
87	MLYS	Mineralys Therapeutics, Inc. Common Stock	Health Care	0.35%	$23.59	-1.23%	-8.05%	-14.23%	35	31	$2.5B
88	STOK	Stoke Therapeutics, Inc. Common Stock	Health Care	0.34%	$25.10	-1.97%	-18.56%	-21.87%	35	68	$1.9B
89	REPL	Replimune Group, Inc.	Health Care	0.33%	$12.91	-1.42%	-16.49%	+16.28%	47	99	$1.4B
90	XNCR	Xencor, Inc.	Health Care	0.32%	$25.97	+3.72%	-11.91%	+65.93%	51	98	$2.0B
91	INBX	Inhibrx Biosciences, Inc. Common Stock	Health Care	0.32%	$95.52	+0.76%	-22.78%	-0.50%	40	99	$1.8B
92	ANAB	AnaptysBio, Inc. Common Stock	Health Care	0.31%	$49.10	+1.34%	-13.54%	-23.41%	28	94	$1.5B
93	ORIC	Oric Pharmaceuticals, Inc. Common Stock	Health Care	0.30%	$12.44	+1.52%	-5.90%	+4.85%	41	62	$1.3B
94	TRAX	First Tracks Biotherapeutics, Inc. Ordinary Shares	Health Care	0.29%	$32.87	-1.59%	-25.18%	+73.06%	37	0	$1.2B
95	ZBIO	Zenas BioPharma, Inc. Common Stock	Health Care	0.29%	$28.09	-0.23%	-12.15%	+5.19%	42	87	$2.1B
96	VIR	Vir Biotechnology, Inc. Common Stock	Health Care	0.29%	$11.66	+2.60%	-3.96%	+12.04%	57	97	$1.9B
97	MNKD	Mannkind Corporation	Health Care	0.28%	$3.77	-1.18%	-4.16%	-15.18%	53	34	$1.3B
98	KURA	Kura Oncology, Inc.	Health Care	0.27%	$10.58	-1.13%	-17.38%	-3.71%	39	81	$1.2B
99	AVBP	ArriVent BioPharma, Inc. Common Stock	Health Care	0.26%	$28.45	+1.06%	-6.79%	-18.76%	43	93	$1.5B
100	ARDX	Ardelyx, Inc.	Health Care	0.24%	$3.38	+1.65%	-10.93%	-35.77%	31	30	$981M
101	TSHA	Taysha Gene Therapies, Inc. Common Stock	Health Care	0.24%	$4.47	-3.56%	-19.20%	-28.22%	33	91	$1.8B
102	TYRA	Tyra Biosciences, Inc. Common Stock	Health Care	0.24%	$20.95	+1.71%	-19.95%	-33.50%	35	92	$1.5B
103	ANNX	Annexon, Inc. Common Stock	Health Care	0.24%	$4.20	-0.24%	-14.49%	-22.84%	46	90	$935M
104	GLUE	Monte Rosa Therapeutics, Inc. Common Stock	Health Care	0.24%	$10.41	-1.00%	-26.98%	-56.23%	24	91	$1.2B
105	JBIO	Jade Biosciences, Inc. Common Stock	Health Care	0.23%	$14.49	+1.98%	-33.30%	-34.08%	25	95	$1.4B
106	RIGL	Rigel Pharmaceuticals Inc. (New)	Health Care	0.22%	$48.22	+1.53%	-1.77%	+21.52%	52	95	$906M
107	CADL	Candel Therapeutics, Inc. Common Stock	Health Care	0.22%	$10.37	+1.57%	-20.53%	+3.04%	39	97	$1.0B
108	AVTX	Avalo Therapeutics, Inc. Common Stock	Health Care	0.22%	$14.62	-2.67%	-21.11%	-21.93%	35	79	$1.0B
109	GERN	Geron Corp	Health Care	0.22%	$1.21	+0.42%	-19.46%	-11.76%	32	43	$1.0B
110	IMMX	Immix Biopharma, Inc. Common Stock	Health Care	0.21%	$10.14	+5.42%	-30.86%	-5.93%	31	100	$994M
111	BCAX	Bicara Therapeutics Inc. Common Stock	Health Care	0.20%	$17.36	-1.42%	-25.42%	-39.21%	24	73	$1.6B
112	CRVS	Corvus Pharmaceuticals, Inc.	Health Care	0.20%	$10.74	-2.29%	-24.20%	-28.29%	31	92	$1.2B
113	VOR	Vor Biopharma Inc. Common Stock	Health Care	0.20%	$19.00	+1.50%	-17.90%	-8.74%	38	25	$1.4B
114	JANX	Janux Therapeutics, Inc. Common Stock	Health Care	0.19%	$16.56	-2.36%	-10.57%	+8.94%	48	34	$1.2B
115	CGEM	Cullinan Therapeutics, Inc. Common Stock	Health Care	0.18%	$16.20	+4.06%	-29.11%	-11.52%	33	99	$1.4B
116	VSTM	Verastem, Inc.	Health Care	0.18%	$7.99	+3.51%	+0.00%	+70.35%	52	42	$723M
117	OLMA	Olema Pharmaceuticals, Inc. Common Stock	Health Care	0.18%	$8.20	-0.18%	-22.26%	-35.57%	27	40	$939M
118	FDMT	4D Molecular Therapeutics, Inc. Common Stock	Health Care	0.16%	$12.90	-6.00%	-5.07%	+5.15%	44	94	$825M
119	SVRA	Savara Inc.	Health Care	0.16%	$4.79	-0.83%	-12.07%	-22.79%	35	89	$1.1B
120	COAG	Hemab Therapeutics Holdings, Inc. Common Stock	Health Care	0.16%	$30.88	-1.45%	-30.11%	-0.64%	23	0	$2.1B
121	CAPR	Capricor Therapeutics Inc	Health Care	0.16%	$7.63	-11.28%	-11.12%	-61.31%	49	83	$575M
122	SANA	Sana Biotechnology, Inc. Common Stock	Health Care	0.16%	$2.92	+0.00%	-24.35%	-27.02%	37	39	$1.2B
123	ACHV	Achieve Life Sciences, Inc.	Health Care	0.16%	$6.98	-3.59%	-12.45%	+12.95%	43	98	$873M
124	RGNX	REGENXBIO Inc.	Health Care	0.15%	$7.80	+5.65%	-20.45%	-45.13%	36	37	$607M
125	DMRA	Damora Therapeutics, Inc. Ordinary Shares	Health Care	0.15%	$20.57	-0.58%	-27.19%	-30.42%	32	0	$1.7B
126	ALLO	Allogene Therapeutics, Inc. Common Stock	Health Care	0.14%	$1.48	-2.67%	-23.86%	-27.88%	25	83	$684M
127	KLRA	Kailera Therapeutics, Inc. Common Stock	Health Care	0.13%	$10.78	+5.29%	-36.61%	-52.79%	28	0	$1.7B
128	CTMX	CytomX Therapeutics, Inc.	Health Care	0.13%	$2.58	+0.00%	-31.18%	-31.91%	32	38	$811M
129	ABUS	Arbutus Biopharma Corporation Common Stock	Health Care	0.13%	$4.71	+5.51%	-12.75%	-8.72%	28	54	$1.0B
130	STTK	Shattuck Labs, Inc. Common Stock	Health Care	0.12%	$6.40	-4.46%	-2.60%	-4.27%	53	99	$699M
131	IRWD	Ironwood Pharmaceuticals, Inc. - Class A	Health Care	0.12%	$3.65	-0.14%	-15.55%	-15.94%	34	99	$729M
132	ALT	Altimmune, Inc. Common Stock	Health Care	0.12%	$2.67	-2.19%	-11.77%	-15.85%	32	35	$638M
133	SLDB	Solid Biosciences Inc. Common Stock	Health Care	0.12%	$7.15	+3.94%	-30.95%	-36.63%	29	73	$1.1B
134	CLYM	Climb Bio, Inc. Common Stock	Health Care	0.12%	$11.06	+0.87%	-26.03%	-19.56%	30	100	$864M
135	SGMT	Sagimet Biosciences Inc. Series A Common Stock	Health Care	0.12%	$8.83	-3.88%	-13.04%	+20.42%	41	88	$679M
136	MYGN	Myriad Genetics Inc	Health Care	0.11%	$4.46	-2.09%	+43.67%	-24.08%	68	31	$309M
137	DSGN	Design Therapeutics, Inc. Common Stock	Health Care	0.11%	$12.55	+1.13%	-19.08%	-20.90%	40	95	$972M
138	OCGN	Ocugen, Inc. Common Stock	Health Care	0.11%	$1.02	+0.49%	-23.88%	-32.45%	40	31	$458M
139	PRME	Prime Medicine, Inc. Common Stock	Health Care	0.11%	$3.12	+4.36%	-14.86%	-22.19%	43	29	$673M
140	MNPR	Monopar Therapeutics Inc. Common Stock	Health Care	0.11%	$79.24	+0.94%	-34.50%	-20.71%	20	55	$796M
141	EDIT	Editas Medicine, Inc. Common Stock	Health Care	0.11%	$2.77	+4.39%	-15.21%	-27.22%	45	36	$473M
142	EBS	Emergent Biosolutions, Inc.	Health Care	0.10%	$7.62	+18.96%	+1.61%	-23.18%	48	35	$331M
143	AKTS	Aktis Oncology, Inc. Common stock	Health Care	0.09%	$18.39	-1.38%	-29.10%	-41.67%	26	100	$1.5B
144	CABA	Cabaletta Bio, Inc. Common Stock	Health Care	0.09%	$2.10	+4.25%	-38.84%	-37.89%	32	41	$605M
145	SPRY	ARS Pharmaceuticals, Inc. Common Stock	Health Care	0.09%	$4.29	+5.53%	-30.55%	-52.56%	34	26	$564M
146	VNDA	Vanda Pharmaceuticals Inc.	Health Care	0.09%	$4.54	-2.05%	-14.26%	-25.68%	33	48	$323M
147	MDXG	MiMedx Group, Inc	Health Care	0.08%	$4.63	+0.54%	+1.55%	+16.20%	49	32	$646M
148	PRTA	Prothena Corporation plc Ordinary Shares	Health Care	0.08%	$8.26	-3.11%	-13.28%	-13.37%	43	41	$493M
149	NGNE	Neurogene, Inc. Common Stock	Health Care	0.07%	$26.65	+3.08%	-32.45%	-27.19%	25	92	$753M
150	ASMB	Assembly Biosciences, Inc	Health Care	0.07%	$22.79	+1.15%	-36.47%	-18.75%	25	43	$748M
151	OVID	Ovid Therapeutics Inc. Common Stock	Health Care	0.07%	$2.33	-2.10%	-14.39%	-14.02%	37	96	$543M
152	FTH	Faeth Therapeutics, Inc. Common Stock	Health Care	0.06%	$27.66	-1.94%	-16.62%	+23.96%	39	0	$891M
153	LXEO	Lexeo Therapeutics, Inc. Common Stock	Health Care	0.06%	$3.65	+1.84%	-25.84%	-24.73%	36	29	$392M
154	AURA	Aura Biosciences, Inc. Common Stock	Health Care	0.06%	$6.38	+4.19%	-18.36%	-21.32%	35	56	$778M
155	CBIO	Crescent Biopharma, Inc. Common Stock	Health Care	0.05%	$14.07	-2.30%	-20.44%	-15.76%	36	82	$689M
156	CMPX	Compass Therapeutics, Inc. Common Stock	Health Care	0.04%	$0.97	+15.27%	-62.91%	-62.26%	14	23	$438M
157	BBOT	BridgeBio Oncology Therapeutics, Inc. Common Stock	Health Care	0.03%	$3.70	-5.53%	-55.85%	-52.21%	21	24	$713M

XBI Holdings FAQ

What is the XBI ETF?

XBI is State Street SPDR S&P Biotech ETF, an exchange-traded fund holding 157 stocks weighted by market capitalization. It packages its underlying basket of companies into a single security, giving investors diversified exposure in one trade.

What are the top holdings of XBI?

The five largest XBI holdings by weight are currently TWST, MRNA, NTRA, UTHR, IOVA. Because XBI is market-cap weighted, its biggest constituents carry the largest weights and have the most influence on the fund's daily moves.

How many stocks does XBI hold?

This snapshot lists 157 holdings for XBI. The count shifts as the fund is rebalanced or reconstituted and as share classes are included.

How concentrated is XBI?

The top 10 XBI holdings account for roughly 16.9% of the fund. Market-cap weighting means a small group of the largest companies can drive a meaningful share of performance.

Which sector does XBI weight the most?

Health Care is the largest sector weight in XBI at about 99.1% across 156 holdings. Sector weights shift over time as constituent prices and membership change.

How often do XBI holdings change?

XBI holdings update as the fund is rebalanced or reconstituted and as daily price moves shift each constituent's market-cap weight. The list on this page reflects the latest available holdings snapshot.