State Street SPDR S&P Biotech ETF

XBI Holdings

The complete, up-to-date list of XBI ETF holdings. XBI holds 146 stocks weighted by market capitalization. Below are all constituents with their ETF weight, sector, price, and recent performance.

Live · 146 quotesAs of September 12, 2026146 holdings

Top 10 XBI Holdings

The 10 largest positions make up about 15.9% of the fund. Because XBI is market-cap weighted, these largest constituents drive most of its day-to-day movement.

MRNAModerna, Inc. Common StockWeight2.87%Price$146.821M+129.92%
TWSTTwist Bioscience Corporation Common StockWeight1.81%Price$134.561M+6.76%
HALOHalozyme Therapeutics, Inc.Weight1.47%Price$107.941M+5.88%
NTRANatera, Inc. Common StockWeight1.46%Price$342.631M+7.59%
KYMRKymera Therapeutics, Inc. Common StockWeight1.44%Price$114.631M-0.09%
TVTXTravere Therapeutics, Inc. Common StockWeight1.40%Price$66.431M+3.89%
ROIVRoivant Sciences Ltd. Common SharesWeight1.39%Price$40.651M+11.77%
ORKAOruka Therapeutics, Inc. Common StockWeight1.38%Price$95.931M-11.52%
RVMDRevolution Medicines, Inc. Common StockWeight1.36%Price$206.051M-0.84%
PRAXPraxis Precision Medicines, Inc. Common StockWeight1.36%Price$332.941M-14.81%

XBI Sector Weights

How State Street SPDR S&P Biotech ETF is allocated across sectors.

Health Care

99.1%145

Finance

0.7%1

Complete XBI Holdings List — All Stocks in XBI by Weight

Every stock in XBI — all 146 constituents — ranked by ETF weight, with price, recent performance, and RSI. Select any ticker for its full quote, chart, and analysis.

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1	MRNA	Moderna, Inc. Common Stock	Health Care	2.87%	$146.82	+1.89%	+129.92%	+193.50%	62	100	$59.4B
2	TWST	Twist Bioscience Corporation Common Stock	Health Care	1.81%	$134.56	+5.91%	+6.76%	+79.62%	56	100	$8.5B
3	HALO	Halozyme Therapeutics, Inc.	Health Care	1.47%	$107.94	+0.66%	+5.88%	+52.01%	64	90	$12.4B
4	NTRA	Natera, Inc. Common Stock	Health Care	1.46%	$342.63	+4.00%	+7.59%	+52.78%	67	97	$47.2B
5	KYMR	Kymera Therapeutics, Inc. Common Stock	Health Care	1.44%	$114.63	-0.31%	-0.09%	+38.89%	47	98	$9.9B
6	TVTX	Travere Therapeutics, Inc. Common Stock	Health Care	1.40%	$66.43	-0.55%	+3.89%	+33.99%	56	98	$6.3B
7	ROIV	Roivant Sciences Ltd. Common Shares	Health Care	1.39%	$40.65	+0.45%	+11.77%	+36.73%	68	99	$24.9B
8	ORKA	Oruka Therapeutics, Inc. Common Stock	Health Care	1.38%	$95.93	+3.85%	-11.52%	+40.41%	50	100	$6.0B
9	RVMD	Revolution Medicines, Inc. Common Stock	Health Care	1.36%	$206.05	+0.62%	-0.84%	+36.38%	50	100	$45.2B
10	PRAX	Praxis Precision Medicines, Inc. Common Stock	Health Care	1.36%	$332.94	-1.23%	-14.81%	+33.69%	41	100	$9.9B
11	INSM	Insmed, Inc.	Health Care	1.34%	$125.81	-3.14%	-5.43%	+31.73%	53	39	$27.7B
12	PTGX	Protagonist Therapeutics, Inc	Health Care	1.33%	$147.71	-0.38%	-3.51%	+34.53%	53	98	$9.6B
13	DNTH	Dianthus Therapeutics, Inc. Common Stock	Health Care	1.31%	$107.67	+1.38%	-4.67%	+39.06%	50	99	$5.9B
14	REGN	Regeneron Pharmaceuticals Inc	Health Care	1.27%	$790.72	+1.54%	-1.06%	+29.46%	50	90	$86.8B
15	CGON	CG Oncology, Inc. Common stock	Health Care	1.27%	$74.18	+1.97%	-4.48%	+27.14%	48	98	$6.6B
16	PCVX	Vaxcyte, Inc. Common Stock	Health Care	1.25%	$59.48	+0.15%	-0.77%	+25.88%	50	96	$9.1B
17	SMMT	Summit Therapeutics Inc. Common Stock	Health Care	1.23%	$18.64	+4.96%	+21.50%	+41.69%	71	58	$13.7B
18	SRRK	Scholar Rock Holding Corporation Common Stock	Health Care	1.22%	$51.05	-6.44%	-5.45%	+15.97%	41	94	$6.8B
19	ERAS	Erasca, Inc. Common Stock	Health Care	1.16%	$16.43	+1.73%	-14.77%	+14.20%	41	100	$5.7B
20	RLAY	Relay Therapeutics, Inc. Common Stock	Health Care	1.16%	$19.07	+1.01%	-6.25%	+34.13%	49	100	$4.2B
21	RYTM	Rhythm Pharmaceuticals, Inc. Common Stock	Health Care	1.15%	$102.40	-2.16%	-13.32%	+16.87%	41	57	$7.2B
22	GILD	Gilead Sciences Inc	Health Care	1.15%	$147.37	+1.88%	+6.92%	+16.08%	56	84	$185.5B
23	TGTX	TG Therapeutics, Inc.	Health Care	1.15%	$54.36	+0.16%	+8.65%	+12.38%	50	95	$8.7B
24	IOVA	Iovance Biotherapeutics, Inc. Common Stock	Health Care	1.15%	$9.23	+7.79%	+37.39%	+134.43%	69	99	$3.9B
25	SYRE	Spyre Therapeutics, Inc. Common Stock	Health Care	1.14%	$90.75	+0.22%	-10.10%	+11.97%	43	100	$7.7B
26	VRTX	Vertex Pharmaceuticals Inc	Health Care	1.14%	$521.04	+0.80%	-1.73%	+18.07%	46	87	$141.4B
27	SLS	SELLAS Life Sciences Group, Inc. Common Stock	Health Care	1.13%	$11.73	+1.56%	+0.21%	+52.83%	42	100	$2.8B
28	ARWR	Arrowhead Research Corporation	Health Care	1.13%	$80.70	-2.66%	-7.91%	+8.24%	39	99	$12.1B
29	INCY	Incyte Genomics Inc	Health Care	1.13%	$121.95	+0.55%	-0.03%	+13.32%	46	90	$26.1B
30	BMRN	BioMarin Pharmaceuticals Inc	Health Care	1.13%	$66.42	+1.13%	-5.60%	+19.57%	56	81	$13.0B
31	VKTX	Viking Therapeutics, Inc	Health Care	1.12%	$31.54	-1.49%	-6.88%	+10.63%	40	81	$4.0B
32	ABBV	ABBVIE INC.	Health Care	1.10%	$261.40	+1.81%	+3.49%	+15.06%	57	78	$462.5B
33	AMGN	Amgen Inc	Health Care	1.09%	$381.50	+1.12%	-9.15%	+6.74%	34	88	$239.4B
34	MDGL	Madrigal Pharmaceuticals, Inc. Common Stock	Health Care	1.09%	$539.59	+0.98%	+0.06%	+13.87%	54	84	$12.5B
35	GRAL	GRAIL, Inc. Common Stock	Health Care	1.07%	$75.09	-0.90%	+9.56%	+25.53%	48	97	$3.6B
36	BIIB	Biogen Inc. Common Stock	Health Care	1.07%	$217.00	+0.16%	+2.06%	+8.37%	53	92	$32.9B
37	ACAD	Acadia Pharmaceuticals Inc.	Health Care	1.07%	$27.46	-1.13%	-7.50%	+28.06%	44	72	$5.0B
38	KRYS	Krystal Biotech, Inc. Common Stock	Health Care	1.07%	$347.40	-2.10%	+2.11%	+2.58%	45	98	$10.9B
39	CYTK	Cytokinetics Inc.	Health Care	1.06%	$72.46	-1.74%	-5.66%	+3.89%	42	89	$10.0B
40	EXEL	Exelixis Inc	Health Care	1.06%	$57.28	+0.16%	+11.22%	+5.07%	51	92	$14.5B
41	COGT	Cogent Biosciences, Inc. Common Stock	Health Care	1.05%	$33.69	-0.01%	-14.46%	+2.55%	35	99	$6.0B
42	BBIO	BridgeBio Pharma, Inc. Common Stock	Health Care	1.04%	$72.91	-0.08%	-14.62%	+6.96%	30	88	$15.0B
43	QURE	uniQure N.V.	Health Care	1.03%	$45.41	+0.85%	-0.07%	+67.21%	46	98	$3.1B
44	MIRM	Mirum Pharmaceuticals, Inc. Common Stock	Health Care	1.03%	$96.77	-1.65%	-2.50%	-3.11%	41	85	$6.1B
45	CRSP	CRISPR Therapeutics AG	Health Care	1.02%	$52.95	+2.37%	-2.43%	+6.36%	44	57	$5.5B
46	ALKS	Alkermes Inc. plc	Health Care	1.02%	$45.48	-0.32%	-11.29%	+1.62%	37	95	$8.0B
47	IMVT	Immunovant, Inc. Common Stock	Health Care	0.95%	$37.63	+0.75%	-12.26%	+14.43%	34	98	$8.2B
48	NBIX	Neurocrine Biosciences Inc	Health Care	0.94%	$157.23	+0.60%	+1.81%	-2.97%	48	68	$16.1B
49	CELC	Celcuity Inc. Common Stock	Health Care	0.94%	$83.39	+0.19%	-9.29%	-6.63%	38	90	$4.7B
50	IBRX	ImmunityBio, Inc. Common Stock	Health Care	0.94%	$8.36	+5.75%	+7.31%	+15.61%	57	99	$8.4B
51	UTHR	United Therapeutics Corp	Health Care	0.89%	$507.83	+1.13%	-2.51%	-8.20%	46	84	$21.0B
52	SRPT	Sarepta Therapeutics,, Inc. Common Stock	Health Care	0.89%	$20.61	+2.25%	+13.63%	+39.37%	55	81	$2.4B
53	PTCT	PTC Therapeutics, Inc.	Health Care	0.89%	$66.47	+0.61%	-9.11%	-11.02%	35	70	$6.0B
54	VERA	Vera Therapeutics, Inc. Class A Common Stock	Health Care	0.86%	$34.65	-2.84%	+13.54%	+0.15%	49	89	$2.5B
55	VRDN	Viridian Therapeutics, Inc. Common Stock	Health Care	0.85%	$22.23	+4.57%	-2.20%	+37.04%	48	69	$2.6B
56	IDYA	IDEAYA Biosciences, Inc. Common Stock	Health Care	0.84%	$38.03	+1.14%	+3.02%	+31.09%	47	93	$3.9B
57	ALNY	Alnylam Pharmaceuticals, Inc.	Health Care	0.82%	$248.84	+0.50%	+10.64%	-13.49%	51	27	$35.8B
58	MLYS	Mineralys Therapeutics, Inc. Common Stock	Health Care	0.80%	$28.93	+2.77%	+6.71%	+20.98%	57	34	$2.5B
59	BEAM	Beam Therapeutics Inc. Common Stock	Health Care	0.80%	$24.18	+0.56%	-11.52%	-18.13%	34	82	$3.0B
60	BCRX	BioCryst Pharmaceuticals Inc	Health Care	0.77%	$8.30	+1.35%	-22.29%	-2.83%	32	57	$2.6B
61	CLDX	Celldex Therapeutics, Inc	Health Care	0.75%	$39.18	+6.17%	-13.18%	+30.86%	49	93	$3.1B
62	DYN	Dyne Therapeutics, Inc. Common Stock	Health Care	0.74%	$18.53	+1.76%	-28.77%	+2.66%	21	90	$4.7B
63	IONS	Ionis Pharmaceuticals, Inc. Common Stock	Health Care	0.73%	$51.61	-5.11%	-8.96%	-30.32%	30	36	$10.2B
64	IMNM	Immunome, Inc.	Health Care	0.73%	$24.84	-0.51%	-14.16%	+33.71%	39	99	$3.1B
65	DNLI	Denali Therapeutics Inc. Common Stock	Health Care	0.72%	$21.84	+0.57%	-15.93%	+0.95%	30	91	$3.7B
66	ADMA	ADMA Biologics, Inc.	Health Care	0.71%	$9.14	-0.92%	-7.21%	+10.25%	43	29	$2.1B
67	IRON	Disc Medicine, Inc. Common Stock	Health Care	0.69%	$68.98	-1.51%	-15.25%	+1.17%	26	73	$3.1B
68	NVAX	Novavax Inc	Health Care	0.68%	$9.55	+1.91%	+19.73%	+5.73%	57	79	$1.7B
69	RXRX	Recursion Pharmaceuticals, Inc. Class A Common Stock	Health Care	0.68%	$3.40	+6.41%	+3.02%	+6.56%	53	34	$1.8B
70	PURR	Hyperliquid Strategies Inc Common Stock	Finance	0.68%	$11.74	+1.98%	+74.78%	+38.11%	60	0	$2.5B
71	NTLA	Intellia Therapeutics, Inc	Health Care	0.67%	$11.97	+1.36%	-1.94%	-3.42%	43	61	$1.8B
72	ARQT	Arcutis Biotherapeutics, Inc. Common Stock	Health Care	0.66%	$24.33	+1.61%	-8.66%	-1.48%	45	89	$3.0B
73	RCUS	Arcus Biosciences, Inc.	Health Care	0.66%	$23.63	-2.11%	-17.37%	+2.43%	27	97	$3.8B
74	TNGX	Tango Therapeutics, Inc.	Health Care	0.66%	$24.57	+3.24%	-5.07%	-16.95%	50	99	$3.8B
75	AGIO	Agios Pharmaceuticals, Inc.	Health Care	0.65%	$33.13	-1.13%	-3.29%	+15.35%	46	43	$2.0B
76	SNDX	Syndax Pharmaceuticals, Inc.	Health Care	0.64%	$18.65	+0.85%	-7.74%	+1.66%	37	75	$1.8B
77	NRIX	Nurix Therapeutics, Inc. Common stock	Health Care	0.62%	$25.54	+1.65%	-5.20%	+48.72%	48	99	$2.6B
78	VCYT	Veracyte, Inc.	Health Care	0.61%	$40.86	+0.83%	-8.89%	-13.26%	39	87	$3.6B
79	PVLA	Palvella Therapeutics, Inc. Common Stock	Health Care	0.60%	$151.66	+1.07%	-2.76%	+42.01%	52	98	$2.2B
80	CDNA	CareDx, Inc.	Health Care	0.56%	$52.56	+4.34%	+10.18%	+122.57%	68	99	$2.6B
81	RARE	Ultragenyx Pharmaceutical Inc.	Health Care	0.51%	$13.68	-4.79%	-49.72%	-43.48%	19	25	$1.5B
82	VIR	Vir Biotechnology, Inc. Common Stock	Health Care	0.51%	$10.74	+1.37%	+19.35%	+24.02%	56	97	$1.9B
83	CGEM	Cullinan Therapeutics, Inc. Common Stock	Health Care	0.49%	$20.10	-0.87%	-1.54%	+56.08%	47	99	$1.4B
84	KOD	Kodiak Sciences Inc Common Stock	Health Care	0.48%	$33.34	+0.82%	-24.37%	-2.47%	31	99	$2.4B
85	BHVN	Biohaven Ltd.	Health Care	0.47%	$12.65	-0.55%	-12.65%	+10.59%	37	41	$2.4B
86	PGEN	Precigen, Inc. Common Stock	Health Care	0.46%	$6.85	+0.00%	-1.72%	+49.89%	52	95	$2.6B
87	XNCR	Xencor, Inc.	Health Care	0.46%	$24.54	+0.49%	+5.01%	+98.78%	49	99	$2.0B
88	STOK	Stoke Therapeutics, Inc. Common Stock	Health Care	0.45%	$29.60	+1.89%	-11.06%	+0.85%	41	86	$1.9B
89	VCEL	Vericel Corporation	Health Care	0.44%	$39.77	+3.21%	-12.66%	+2.67%	40	84	$2.1B
90	INBX	Inhibrx Biosciences, Inc. Common Stock	Health Care	0.43%	$110.38	+1.49%	+10.53%	+24.64%	52	99	$1.8B
91	ANAB	AnaptysBio, Inc. Common Stock	Health Care	0.42%	$54.15	+0.40%	-5.19%	-1.39%	41	98	$1.7B
92	ABSI	Absci Corporation Common Stock	Health Care	0.41%	$8.15	-1.58%	-15.55%	+22.58%	41	99	$1.5B
93	ZBIO	Zenas BioPharma, Inc. Common Stock	Health Care	0.41%	$32.49	+2.54%	+5.00%	+79.47%	51	94	$2.1B
94	ORIC	Oric Pharmaceuticals, Inc. Common Stock	Health Care	0.38%	$12.65	+5.19%	-8.93%	+59.32%	49	79	$1.3B
95	VOR	Vor Biopharma Inc. Common Stock	Health Care	0.38%	$23.10	+3.36%	+4.86%	+63.80%	51	30	$1.4B
96	CRVS	Corvus Pharmaceuticals, Inc.	Health Care	0.37%	$13.13	+1.55%	-14.03%	+13.80%	39	98	$1.2B
97	REPL	Replimune Group, Inc.	Health Care	0.35%	$13.15	+1.51%	-12.60%	+55.15%	44	98	$1.4B
98	KURA	Kura Oncology, Inc.	Health Care	0.35%	$11.64	+1.45%	+9.01%	+30.62%	47	90	$1.2B
99	TRAX	First Tracks Biotherapeutics, Inc. Ordinary Shares	Health Care	0.34%	$37.58	+3.13%	-18.59%	+120.61%	42	0	$1.6B
100	AVTX	Avalo Therapeutics, Inc. Common Stock	Health Care	0.34%	$16.18	+0.34%	-17.66%	+14.83%	33	91	$1.0B
101	JANX	Janux Therapeutics, Inc. Common Stock	Health Care	0.33%	$17.30	+1.17%	+3.41%	+26.91%	46	33	$1.2B
102	TYRA	Tyra Biosciences, Inc. Common Stock	Health Care	0.32%	$23.69	+13.78%	-1.03%	-2.22%	47	97	$1.5B
103	MNKD	Mannkind Corporation	Health Care	0.31%	$3.77	+0.27%	-3.35%	+0.00%	42	31	$1.3B
104	RIGL	Rigel Pharmaceuticals Inc. (New)	Health Care	0.30%	$45.71	-4.02%	+6.66%	+41.37%	51	82	$906M
105	GLUE	Monte Rosa Therapeutics, Inc. Common Stock	Health Care	0.29%	$13.91	-1.07%	-13.56%	-20.55%	37	99	$1.2B
106	GERN	Geron Corp	Health Care	0.29%	$1.36	+1.11%	-13.29%	+20.18%	41	61	$1.0B
107	JBIO	Jade Biosciences, Inc. Common Stock	Health Care	0.29%	$18.18	+1.73%	-22.70%	+14.48%	34	98	$1.4B
108	OLMA	Olema Pharmaceuticals, Inc. Common Stock	Health Care	0.28%	$10.10	+0.68%	-0.68%	+5.32%	43	87	$939M
109	TSHA	Taysha Gene Therapies, Inc. Common Stock	Health Care	0.28%	$5.04	-0.10%	-21.72%	-10.22%	30	93	$1.8B
110	ARDX	Ardelyx, Inc.	Health Care	0.26%	$3.54	-1.96%	-12.66%	-39.31%	26	27	$981M
111	IMMX	Immix Biopharma, Inc. Common Stock	Health Care	0.26%	$12.08	+0.41%	+6.08%	+49.18%	47	100	$994M
112	CTMX	CytomX Therapeutics, Inc.	Health Care	0.26%	$3.21	-2.43%	-8.57%	+7.38%	41	92	$811M
113	ALT	Altimmune, Inc. Common Stock	Health Care	0.26%	$3.32	+0.92%	+11.86%	+26.44%	58	42	$638M
114	VSTM	Verastem, Inc.	Health Care	0.25%	$7.40	+2.87%	+6.37%	+90.61%	56	34	$723M
115	ANNX	Annexon, Inc. Common Stock	Health Care	0.25%	$3.94	+0.38%	-26.31%	-15.96%	26	95	$935M
116	BCAX	Bicara Therapeutics Inc. Common Stock	Health Care	0.25%	$23.21	+1.53%	-6.79%	+9.18%	42	96	$1.6B
117	AVBP	ArriVent BioPharma, Inc. Common Stock	Health Care	0.24%	$29.63	-1.55%	-7.03%	-5.40%	40	92	$1.5B
118	SLDB	Solid Biosciences Inc. Common Stock	Health Care	0.23%	$8.96	+0.52%	-4.38%	+20.39%	42	94	$1.1B
119	CADL	Candel Therapeutics, Inc. Common Stock	Health Care	0.22%	$10.56	+1.28%	-1.61%	+29.71%	39	98	$1.0B
120	SANA	Sana Biotechnology, Inc. Common Stock	Health Care	0.21%	$3.20	+2.24%	-15.12%	+15.52%	39	66	$1.2B
121	IRWD	Ironwood Pharmaceuticals, Inc. - Class A	Health Care	0.21%	$4.13	+2.08%	-5.44%	+14.25%	50	99	$729M
122	FDMT	4D Molecular Therapeutics, Inc. Common Stock	Health Care	0.21%	$13.75	+4.33%	+15.34%	+52.89%	50	97	$825M
123	ALLO	Allogene Therapeutics, Inc. Common Stock	Health Care	0.21%	$1.80	+0.00%	-16.43%	-5.32%	39	94	$684M
124	DMRA	Damora Therapeutics, Inc. Ordinary Shares	Health Care	0.19%	$28.99	+0.85%	-8.80%	+32.60%	47	0	$1.7B
125	ABUS	Arbutus Biopharma Corporation Common Stock	Health Care	0.18%	$5.15	+0.00%	+12.50%	+20.14%	60	66	$1.0B
126	CAPR	Capricor Therapeutics Inc	Health Care	0.18%	$8.80	+5.02%	+110.77%	-65.26%	47	88	$575M
127	PRME	Prime Medicine, Inc. Common Stock	Health Care	0.17%	$3.25	+1.92%	-1.55%	+12.77%	43	37	$673M
128	SVRA	Savara Inc.	Health Care	0.17%	$5.50	+0.75%	-7.13%	+1.33%	45	89	$1.1B
129	RGNX	REGENXBIO Inc.	Health Care	0.16%	$8.81	+1.82%	-21.21%	+36.64%	41	42	$607M
130	CABA	Cabaletta Bio, Inc. Common Stock	Health Care	0.14%	$2.97	+6.41%	+2.11%	-3.00%	46	94	$605M
131	OCGN	Ocugen, Inc. Common Stock	Health Care	0.14%	$1.06	+4.90%	-24.82%	-13.11%	32	57	$458M
132	CMPX	Compass Therapeutics, Inc. Common Stock	Health Care	0.14%	$2.00	-1.50%	-16.95%	-2.00%	35	28	$438M
133	MDXG	MiMedx Group, Inc	Health Care	0.13%	$4.64	+1.75%	+8.41%	+25.75%	61	31	$646M
134	PRTA	Prothena Corporation plc Ordinary Shares	Health Care	0.13%	$8.86	-0.84%	-4.73%	+7.26%	43	63	$493M
135	OVID	Ovid Therapeutics Inc. Common Stock	Health Care	0.13%	$2.76	+2.04%	+3.40%	+24.55%	52	97	$543M
136	SPRY	ARS Pharmaceuticals, Inc. Common Stock	Health Care	0.11%	$4.84	-5.57%	-25.99%	-53.75%	28	25	$564M
137	VNDA	Vanda Pharmaceuticals Inc.	Health Care	0.11%	$5.20	+0.98%	-0.96%	-15.44%	44	73	$323M
138	CATX	Perspective Therapeutics, Inc.	Health Care	0.11%	$2.85	+1.42%	-10.43%	-0.68%	43	42	$354M
139	SGMT	Sagimet Biosciences Inc. Series A Common Stock	Health Care	0.11%	$11.01	+0.05%	+14.29%	+69.21%	63	92	$679M
140	LXEO	Lexeo Therapeutics, Inc. Common Stock	Health Care	0.10%	$4.25	-0.94%	-14.95%	+0.00%	35	36	$392M
141	MYGN	Myriad Genetics Inc	Health Care	0.10%	$3.77	+11.40%	+16.98%	-18.14%	60	28	$309M
142	EBS	Emergent Biosolutions, Inc.	Health Care	0.10%	$6.38	+2.41%	+41.15%	-23.41%	57	36	$331M
143	ACHV	Achieve Life Sciences, Inc.	Health Care	0.10%	$7.37	+2.27%	+4.48%	+30.98%	45	98	$873M
144	MPLT	MapLight Therapeutics, Inc. Common Stock	Health Care	0.07%	$13.06	+1.12%	+10.32%	-57.37%	41	0	$609M
145	SION	Sionna Therapeutics, Inc. Common Stock	Health Care	0.05%	$7.92	+5.22%	+31.32%	-77.09%	33	24	$305M
146	BBOT	BridgeBio Oncology Therapeutics, Inc. Common Stock	Health Care	0.04%	$5.02	+1.92%	-46.73%	-32.31%	18	27	$713M

XBI Holdings FAQ

What is the XBI ETF?

XBI is State Street SPDR S&P Biotech ETF, an exchange-traded fund holding 146 stocks weighted by market capitalization. It packages its underlying basket of companies into a single security, giving investors diversified exposure in one trade.

What are the top holdings of XBI?

The five largest XBI holdings by weight are currently MRNA, TWST, HALO, NTRA, KYMR. Because XBI is market-cap weighted, its biggest constituents carry the largest weights and have the most influence on the fund's daily moves.

How many stocks does XBI hold?

This snapshot lists 146 holdings for XBI. The count shifts as the fund is rebalanced or reconstituted and as share classes are included.

How concentrated is XBI?

The top 10 XBI holdings account for roughly 15.9% of the fund. Market-cap weighting means a small group of the largest companies can drive a meaningful share of performance.

Which sector does XBI weight the most?

Health Care is the largest sector weight in XBI at about 99.1% across 145 holdings. Sector weights shift over time as constituent prices and membership change.

How often do XBI holdings change?

XBI holdings update as the fund is rebalanced or reconstituted and as daily price moves shift each constituent's market-cap weight. The list on this page reflects the latest available holdings snapshot.