State Street SPDR S&P Biotech ETF
XBI Holdings
The complete, up-to-date list of XBI ETF holdings. XBI holds 147 stocks weighted by market capitalization. Below are all constituents with their ETF weight, sector, price, and recent performance.
Top 10 XBI Holdings
The 10 largest positions make up about 15.7% of the fund. Because XBI is market-cap weighted, these largest constituents drive most of its day-to-day movement.
- MRNAModerna, Inc. Common StockWeight2.65%Price$158.941M+190.10%
- TWSTTwist Bioscience Corporation Common StockWeight1.84%Price$151.551M+61.95%
- ORKAOruka Therapeutics, Inc. Common StockWeight1.50%Price$101.671M+11.04%
- APGEApogee Therapeutics, Inc. Common StockWeight1.49%Price$134.881M+0.42%
- KYMRKymera Therapeutics, Inc. Common StockWeight1.42%Price$126.721M+14.53%
- PRAXPraxis Precision Medicines, Inc. Common StockWeight1.39%Price$365.631M+13.13%
- HALOHalozyme Therapeutics, Inc.Weight1.38%Price$109.311M+32.65%
- NTRANatera, Inc. Common StockWeight1.37%Price$339.501M+27.62%
- RVMDRevolution Medicines, Inc. Common StockWeight1.34%Price$210.951M+11.89%
- SYRESpyre Therapeutics, Inc. Common StockWeight1.31%Price$95.291M+5.24%
XBI Sector Weights
How State Street SPDR S&P Biotech ETF is allocated across sectors.
Complete XBI Holdings List — All Stocks in XBI by Weight
Every stock in XBI — all 147 constituents — ranked by ETF weight, with price, recent performance, and RSI. Select any ticker for its full quote, chart, and analysis.
| # | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | MRNA | Moderna, Inc. Common Stock | Health Care | 2.65% | $158.94 | +14.35% | +190.10% | +236.43% | 73 | 100 | $22.0B |
| 2 | TWST | Twist Bioscience Corporation Common Stock | Health Care | 1.84% | $151.55 | +7.69% | +61.95% | +148.07% | 70 | 100 | $6.3B |
| 3 | ORKA | Oruka Therapeutics, Inc. Common Stock | Health Care | 1.50% | $101.67 | -0.54% | +11.04% | +65.00% | 52 | 100 | $5.7B |
| 4 | APGE | Apogee Therapeutics, Inc. Common Stock | Health Care | 1.49% | $134.88 | +0.04% | +0.42% | +63.97% | 78 | 99 | $10.1B |
| 5 | KYMR | Kymera Therapeutics, Inc. Common Stock | Health Care | 1.42% | $126.72 | +4.67% | +14.53% | +59.96% | 67 | 98 | $8.5B |
| 6 | PRAX | Praxis Precision Medicines, Inc. Common Stock | Health Care | 1.39% | $365.63 | -0.01% | +13.13% | +6.98% | 57 | 100 | $8.5B |
| 7 | HALO | Halozyme Therapeutics, Inc. | Health Care | 1.38% | $109.31 | +0.65% | +32.65% | +58.53% | 79 | 90 | $9.8B |
| 8 | NTRA | Natera, Inc. Common Stock | Health Care | 1.37% | $339.50 | +2.74% | +27.62% | +63.87% | 72 | 96 | $38.7B |
| 9 | RVMD | Revolution Medicines, Inc. Common Stock | Health Care | 1.34% | $210.95 | -0.17% | +11.89% | +38.05% | 64 | 100 | $38.8B |
| 10 | SYRE | Spyre Therapeutics, Inc. Common Stock | Health Care | 1.31% | $95.29 | -12.80% | +5.24% | +43.40% | 59 | 100 | $8.2B |
| 11 | DNTH | Dianthus Therapeutics, Inc. Common Stock | Health Care | 1.31% | $111.98 | +1.84% | +7.96% | +28.07% | 55 | 99 | $5.8B |
| 12 | PTGX | Protagonist Therapeutics, Inc | Health Care | 1.30% | $149.50 | -2.71% | +10.64% | +50.54% | 57 | 98 | $8.5B |
| 13 | CGON | CG Oncology, Inc. Common stock | Health Care | 1.29% | $78.61 | +0.95% | +12.69% | +23.36% | 59 | 98 | $6.3B |
| 14 | TVTX | Travere Therapeutics, Inc. Common Stock | Health Care | 1.26% | $67.24 | +2.88% | +15.63% | +50.82% | 69 | 99 | $5.1B |
| 15 | REGN | Regeneron Pharmaceuticals Inc | Health Care | 1.26% | $833.61 | +0.66% | +25.96% | +29.75% | 74 | 86 | $78.2B |
| 16 | INSM | Insmed, Inc. | Health Care | 1.25% | $124.09 | -0.10% | +15.86% | +14.90% | 56 | 41 | $21.4B |
| 17 | PCVX | Vaxcyte, Inc. Common Stock | Health Care | 1.24% | $61.12 | -1.13% | +11.54% | +27.96% | 58 | 95 | $7.7B |
| 18 | IOVA | Iovance Biotherapeutics, Inc. Common Stock | Health Care | 1.20% | $8.43 | +4.78% | +68.13% | +107.12% | 71 | 99 | $1.8B |
| 19 | ROIV | Roivant Sciences Ltd. Common Shares | Health Care | 1.19% | $36.48 | +0.36% | +3.81% | +21.65% | 57 | 99 | $24.1B |
| 20 | ERAS | Erasca, Inc. Common Stock | Health Care | 1.17% | $17.77 | +0.94% | -6.67% | +56.34% | 48 | 100 | $6.3B |
| 21 | AMGN | Amgen Inc | Health Care | 1.17% | $441.95 | -0.36% | +16.82% | +29.86% | 73 | 90 | $207.9B |
| 22 | RYTM | Rhythm Pharmaceuticals, Inc. Common Stock | Health Care | 1.16% | $112.95 | +1.71% | +8.32% | +27.66% | 55 | 62 | $7.1B |
| 23 | SRRK | Scholar Rock Holding Corporation Common Stock | Health Care | 1.15% | $58.92 | +0.11% | +19.78% | +21.03% | 66 | 93 | $5.5B |
| 24 | RLAY | Relay Therapeutics, Inc. Common Stock | Health Care | 1.14% | $19.89 | +4.15% | +11.37% | +47.88% | 60 | 100 | $4.1B |
| 25 | VRTX | Vertex Pharmaceuticals Inc | Health Care | 1.13% | $554.68 | +1.00% | +15.35% | +26.22% | 68 | 86 | $119.5B |
| 26 | VKTX | Viking Therapeutics, Inc | Health Care | 1.13% | $34.25 | +2.83% | -3.50% | +10.51% | 50 | 85 | $3.8B |
| 27 | ARWR | Arrowhead Research Corporation | Health Care | 1.13% | $88.86 | +2.43% | +3.63% | +18.40% | 57 | 99 | $11.9B |
| 28 | BBIO | BridgeBio Pharma, Inc. Common Stock | Health Care | 1.13% | $80.34 | -0.80% | -4.41% | +17.39% | 47 | 91 | $15.7B |
| 29 | INCY | Incyte Genomics Inc | Health Care | 1.11% | $130.24 | +1.37% | +10.24% | +33.25% | 68 | 89 | $24.2B |
| 30 | BMRN | BioMarin Pharmaceuticals Inc | Health Care | 1.10% | $66.11 | +1.58% | +10.40% | +21.99% | 56 | 65 | $11.6B |
| 31 | GILD | Gilead Sciences Inc | Health Care | 1.08% | $148.52 | +1.39% | +13.56% | +10.00% | 70 | 81 | $161.7B |
| 32 | QURE | uniQure N.V. | Health Care | 1.08% | $51.33 | +7.49% | +32.60% | +109.14% | 69 | 99 | $3.1B |
| 33 | CRSP | CRISPR Therapeutics AG | Health Care | 1.08% | $60.38 | +6.63% | +27.78% | +20.17% | 66 | 67 | $4.7B |
| 34 | SLS | SELLAS Life Sciences Group, Inc. Common Stock | Health Care | 1.07% | $14.15 | -1.71% | +25.13% | +80.64% | 60 | 100 | $2.2B |
| 35 | ABBV | ABBVIE INC. | Health Care | 1.06% | $265.61 | +0.48% | +2.62% | +23.10% | 65 | 80 | $443.4B |
| 36 | ACAD | Acadia Pharmaceuticals Inc. | Health Care | 1.06% | $30.70 | +3.17% | +21.21% | +45.09% | 68 | 76 | $4.4B |
| 37 | CYTK | Cytokinetics Inc. | Health Care | 1.05% | $77.56 | +0.46% | -4.97% | +0.58% | 49 | 96 | $10.5B |
| 38 | IMVT | Immunovant, Inc. Common Stock | Health Care | 1.05% | $44.28 | +0.44% | +8.83% | +24.46% | 63 | 98 | $7.9B |
| 39 | COGT | Cogent Biosciences, Inc. Common Stock | Health Care | 1.03% | $37.19 | +1.63% | -8.11% | +10.76% | 44 | 99 | $6.7B |
| 40 | GRAL | GRAIL, Inc. Common Stock | Health Care | 1.02% | $82.70 | +7.65% | +18.49% | +22.57% | 63 | 98 | $2.9B |
| 41 | BIIB | Biogen Inc. Common Stock | Health Care | 1.01% | $221.76 | +1.12% | +8.89% | +13.62% | 62 | 91 | $30.0B |
| 42 | MDGL | Madrigal Pharmaceuticals, Inc. Common Stock | Health Care | 1.01% | $511.44 | +0.08% | -7.72% | -0.84% | 47 | 80 | $11.1B |
| 43 | ALKS | Alkermes Inc. plc | Health Care | 1.00% | $49.23 | +0.70% | -6.93% | +33.72% | 48 | 93 | $8.2B |
| 44 | TGTX | TG Therapeutics, Inc. | Health Care | 0.99% | $55.23 | -1.06% | -3.28% | +42.03% | 61 | 95 | $7.1B |
| 45 | DYN | Dyne Therapeutics, Inc. Common Stock | Health Care | 0.99% | $26.34 | +1.39% | +5.36% | +44.61% | 59 | 96 | $4.7B |
| 46 | KRYS | Krystal Biotech, Inc. Common Stock | Health Care | 0.99% | $359.69 | +4.13% | +5.07% | +17.93% | 58 | 97 | $10.1B |
| 47 | MIRM | Mirum Pharmaceuticals, Inc. Common Stock | Health Care | 0.95% | $98.18 | +1.34% | -14.82% | -0.77% | 41 | 87 | $6.4B |
| 48 | CELC | Celcuity Inc. Common Stock | Health Care | 0.94% | $94.27 | +1.55% | +10.77% | -34.49% | 50 | 94 | $4.2B |
| 49 | EXEL | Exelixis Inc | Health Care | 0.93% | $56.45 | +4.00% | +1.63% | +12.21% | 60 | 89 | $13.3B |
| 50 | IBRX | ImmunityBio, Inc. Common Stock | Health Care | 0.90% | $8.15 | +7.98% | +12.97% | +12.50% | 58 | 99 | $7.5B |
| 51 | VRDN | Viridian Therapeutics, Inc. Common Stock | Health Care | 0.88% | $24.34 | +0.75% | +23.56% | +34.33% | 67 | 84 | $2.1B |
| 52 | BEAM | Beam Therapeutics Inc. Common Stock | Health Care | 0.88% | $31.03 | +9.55% | +21.93% | +6.49% | 61 | 95 | $2.6B |
| 53 | PTCT | PTC Therapeutics, Inc. | Health Care | 0.88% | $73.36 | +3.32% | -5.35% | +6.69% | 50 | 89 | $5.7B |
| 54 | UTHR | United Therapeutics Corp | Health Care | 0.88% | $518.65 | +1.12% | -2.11% | -8.16% | 48 | 93 | $21.9B |
| 55 | NBIX | Neurocrine Biosciences Inc | Health Care | 0.87% | $154.57 | +0.20% | -13.09% | -2.93% | 38 | 64 | $16.9B |
| 56 | RARE | Ultragenyx Pharmaceutical Inc. | Health Care | 0.85% | $26.64 | +2.86% | -3.32% | +12.02% | 49 | 38 | $2.5B |
| 57 | SMMT | Summit Therapeutics Inc. Common Stock | Health Care | 0.85% | $13.54 | +4.95% | -3.54% | -19.42% | 48 | 26 | $10.4B |
| 58 | BCRX | BioCryst Pharmaceuticals Inc | Health Care | 0.85% | $9.85 | +1.76% | +1.97% | +20.10% | 53 | 70 | $2.3B |
| 59 | IDYA | IDEAYA Biosciences, Inc. Common Stock | Health Care | 0.83% | $42.69 | +6.09% | +16.83% | +45.73% | 78 | 93 | $3.4B |
| 60 | DNLI | Denali Therapeutics Inc. Common Stock | Health Care | 0.80% | $25.23 | +3.06% | +5.68% | +32.18% | 54 | 92 | $3.7B |
| 61 | SRPT | Sarepta Therapeutics,, Inc. Common Stock | Health Care | 0.79% | $18.75 | +4.38% | +14.95% | +12.02% | 59 | 41 | $1.7B |
| 62 | IMNM | Immunome, Inc. | Health Care | 0.77% | $29.35 | +5.00% | +30.08% | +35.98% | 66 | 98 | $2.6B |
| 63 | VERA | Vera Therapeutics, Inc. Class A Common Stock | Health Care | 0.76% | $35.48 | +4.83% | -1.84% | +2.47% | 57 | 91 | $2.3B |
| 64 | CLDX | Celldex Therapeutics, Inc | Health Care | 0.74% | $41.22 | +1.68% | +15.53% | +33.66% | 57 | 95 | $3.0B |
| 65 | IONS | Ionis Pharmaceuticals, Inc. Common Stock | Health Care | 0.73% | $63.80 | +2.43% | +11.67% | -16.36% | 61 | 89 | $8.6B |
| 66 | ALNY | Alnylam Pharmaceuticals, Inc. | Health Care | 0.72% | $240.13 | +1.68% | -11.95% | -19.71% | 49 | 26 | $27.5B |
| 67 | RCUS | Arcus Biosciences, Inc. | Health Care | 0.70% | $31.56 | +4.81% | +10.12% | +34.86% | 65 | 98 | $3.5B |
| 68 | ADMA | ADMA Biologics, Inc. | Health Care | 0.70% | $9.73 | +1.88% | +15.99% | +18.25% | 57 | 28 | $2.0B |
| 69 | IRON | Disc Medicine, Inc. Common Stock | Health Care | 0.69% | $82.41 | +1.94% | +10.74% | +22.69% | 63 | 86 | $3.0B |
| 70 | RXRX | Recursion Pharmaceuticals, Inc. Class A Common Stock | Health Care | 0.68% | $3.54 | +9.54% | +17.49% | +17.49% | 58 | 32 | $1.7B |
| 71 | ARQT | Arcutis Biotherapeutics, Inc. Common Stock | Health Care | 0.68% | $24.70 | +0.28% | -9.99% | +18.55% | 41 | 92 | $3.4B |
| 72 | MLYS | Mineralys Therapeutics, Inc. Common Stock | Health Care | 0.67% | $26.34 | +4.27% | -3.23% | -12.84% | 49 | 94 | $2.3B |
| 73 | NTLA | Intellia Therapeutics, Inc | Health Care | 0.66% | $13.46 | +7.64% | +22.93% | +6.63% | 59 | 83 | $1.5B |
| 74 | SNDX | Syndax Pharmaceuticals, Inc. | Health Care | 0.64% | $19.94 | +1.84% | -5.55% | -0.35% | 48 | 79 | $1.7B |
| 75 | TNGX | Tango Therapeutics, Inc. | Health Care | 0.62% | $24.73 | +1.02% | -7.61% | +20.18% | 42 | 99 | $4.4B |
| 76 | AGIO | Agios Pharmaceuticals, Inc. | Health Care | 0.62% | $33.90 | +3.78% | -8.48% | +20.00% | 49 | 38 | $1.8B |
| 77 | NRIX | Nurix Therapeutics, Inc. Common stock | Health Care | 0.61% | $26.93 | +2.63% | +13.95% | +53.56% | 63 | 98 | $2.4B |
| 78 | PURR | Hyperliquid Strategies Inc Common Stock | Finance | 0.59% | $11.74 | +11.51% | +86.64% | +41.82% | 84 | 0 | $1.3B |
| 79 | NVAX | Novavax Inc | Health Care | 0.58% | $9.44 | +6.55% | +21.65% | +0.64% | 68 | 76 | $1.2B |
| 80 | VCYT | Veracyte, Inc. | Health Care | 0.57% | $44.30 | +6.29% | -23.78% | -2.89% | 43 | 89 | $3.6B |
| 81 | KOD | Kodiak Sciences Inc Common Stock | Health Care | 0.55% | $39.06 | +6.02% | -4.71% | +8.02% | 47 | 99 | $2.6B |
| 82 | PVLA | Palvella Therapeutics, Inc. Common Stock | Health Care | 0.54% | $148.01 | +1.51% | +6.42% | +28.61% | 51 | 98 | $2.0B |
| 83 | CDNA | CareDx, Inc. | Health Care | 0.49% | $51.30 | +6.99% | +36.52% | +133.56% | 73 | 99 | $2.3B |
| 84 | PGEN | Precigen, Inc. Common Stock | Health Care | 0.49% | $7.52 | +1.53% | +34.57% | +69.70% | 64 | 96 | $2.4B |
| 85 | XNCR | Xencor, Inc. | Health Care | 0.48% | $29.40 | +1.05% | +50.40% | +157.02% | 83 | 99 | $1.4B |
| 86 | BHVN | Biohaven Ltd. | Health Care | 0.47% | $14.20 | +5.41% | -1.64% | +51.37% | 52 | 38 | $2.0B |
| 87 | CGEM | Cullinan Therapeutics, Inc. Common Stock | Health Care | 0.47% | $22.96 | +5.32% | +31.52% | +62.19% | 74 | 98 | $1.0B |
| 88 | VCEL | Vericel Corporation | Health Care | 0.46% | $43.20 | +2.10% | -4.97% | +24.20% | 45 | 75 | $2.4B |
| 89 | STOK | Stoke Therapeutics, Inc. Common Stock | Health Care | 0.46% | $33.46 | +3.43% | +13.12% | +13.42% | 61 | 93 | $1.8B |
| 90 | ABSI | Absci Corporation Common Stock | Health Care | 0.44% | $9.68 | +9.05% | +23.38% | +84.48% | 56 | 99 | $1.3B |
| 91 | VIR | Vir Biotechnology, Inc. Common Stock | Health Care | 0.42% | $10.95 | +8.17% | +21.43% | +15.91% | 69 | 97 | $1.5B |
| 92 | ORIC | Oric Pharmaceuticals, Inc. Common Stock | Health Care | 0.42% | $13.82 | +2.75% | +14.20% | +65.83% | 59 | 87 | $1.1B |
| 93 | ANAB | AnaptysBio, Inc. Common Stock | Health Care | 0.41% | $58.30 | +0.01% | +7.83% | -2.72% | 53 | 98 | $1.7B |
| 94 | ZBIO | Zenas BioPharma, Inc. Common Stock | Health Care | 0.39% | $33.72 | +6.67% | +9.25% | +75.52% | 63 | 95 | $2.0B |
| 95 | CRVS | Corvus Pharmaceuticals, Inc. | Health Care | 0.39% | $14.72 | +3.41% | +10.55% | +13.84% | 53 | 98 | $1.1B |
| 96 | VOR | Vor Biopharma Inc. Common Stock | Health Care | 0.37% | $24.15 | +5.66% | +23.64% | +64.56% | 64 | 27 | $1.2B |
| 97 | AVTX | Avalo Therapeutics, Inc. Common Stock | Health Care | 0.37% | $19.75 | +2.46% | +6.73% | +19.13% | 54 | 96 | $965M |
| 98 | INBX | Inhibrx Biosciences, Inc. Common Stock | Health Care | 0.37% | $122.92 | +17.34% | +48.55% | +15.95% | 75 | 100 | $1.2B |
| 99 | TRAX | First Tracks Biotherapeutics, Inc. Ordinary Shares | Health Care | 0.36% | $44.98 | +4.32% | +4.01% | +162.27% | 60 | 0 | $1.2B |
| 100 | REPL | Replimune Group, Inc. | Health Care | 0.36% | $15.73 | +7.41% | +53.40% | +200.95% | 65 | 98 | $1.0B |
| 101 | MNKD | Mannkind Corporation | Health Care | 0.33% | $4.27 | +2.46% | -1.19% | +21.28% | 54 | 55 | $1.2B |
| 102 | KURA | Kura Oncology, Inc. | Health Care | 0.33% | $13.64 | +9.52% | +26.71% | +19.84% | 74 | 94 | $800M |
| 103 | TYRA | Tyra Biosciences, Inc. Common Stock | Health Care | 0.33% | $26.61 | +2.45% | -13.32% | -18.50% | 44 | 97 | $1.9B |
| 104 | TSHA | Taysha Gene Therapies, Inc. Common Stock | Health Care | 0.31% | $6.12 | +3.69% | +9.35% | +11.31% | 52 | 96 | $1.7B |
| 105 | GERN | Geron Corp | Health Care | 0.31% | $1.55 | +2.63% | +6.90% | +19.23% | 55 | 61 | $828M |
| 106 | JANX | Janux Therapeutics, Inc. Common Stock | Health Care | 0.31% | $18.70 | +0.48% | +19.74% | +28.38% | 73 | 33 | $925M |
| 107 | JBIO | Jade Biosciences, Inc. Common Stock | Health Care | 0.30% | $21.86 | +2.58% | +7.96% | +1.35% | 51 | 98 | $1.2B |
| 108 | ANNX | Annexon, Inc. Common Stock | Health Care | 0.30% | $5.09 | +1.68% | -2.83% | -4.81% | 46 | 97 | $835M |
| 109 | GLUE | Monte Rosa Therapeutics, Inc. Common Stock | Health Care | 0.29% | $14.66 | +5.66% | -37.67% | -23.77% | 34 | 99 | $1.4B |
| 110 | OLMA | Olema Pharmaceuticals, Inc. Common Stock | Health Care | 0.27% | $10.90 | +4.55% | -8.47% | -20.74% | 47 | 95 | $985M |
| 111 | RIGL | Rigel Pharmaceuticals Inc. (New) | Health Care | 0.27% | $46.07 | +3.48% | +25.34% | +60.27% | 67 | 60 | $693M |
| 112 | ARDX | Ardelyx, Inc. | Health Care | 0.27% | $3.83 | +1.07% | -26.32% | -38.64% | 26 | 29 | $1.2B |
| 113 | IMMX | Immix Biopharma, Inc. Common Stock | Health Care | 0.26% | $15.78 | +7.20% | +67.67% | +62.77% | 77 | 100 | $592M |
| 114 | BCAX | Bicara Therapeutics Inc. Common Stock | Health Care | 0.25% | $24.59 | +4.22% | -10.16% | +12.65% | 46 | 96 | $1.8B |
| 115 | SANA | Sana Biotechnology, Inc. Common Stock | Health Care | 0.24% | $4.07 | +8.73% | +26.93% | +33.12% | 62 | 64 | $885M |
| 116 | CTMX | CytomX Therapeutics, Inc. | Health Care | 0.24% | $3.37 | +2.28% | +3.69% | -10.13% | 49 | 93 | $675M |
| 117 | FDMT | 4D Molecular Therapeutics, Inc. Common Stock | Health Care | 0.24% | $15.69 | +2.01% | +53.82% | +80.28% | 71 | 97 | $532M |
| 118 | AVBP | ArriVent BioPharma, Inc. Common Stock | Health Care | 0.24% | $31.39 | +11.02% | -1.60% | +15.85% | 54 | 91 | $1.4B |
| 119 | ALLO | Allogene Therapeutics, Inc. Common Stock | Health Care | 0.23% | $2.17 | +6.65% | +20.56% | +6.90% | 58 | 95 | $649M |
| 120 | CADL | Candel Therapeutics, Inc. Common Stock | Health Care | 0.23% | $13.53 | +5.64% | +43.01% | +67.28% | 70 | 97 | $733M |
| 121 | ALT | Altimmune, Inc. Common Stock | Health Care | 0.22% | $3.19 | +2.89% | +14.29% | +10.34% | 60 | 39 | $552M |
| 122 | SLDB | Solid Biosciences Inc. Common Stock | Health Care | 0.22% | $9.89 | +8.08% | +23.47% | +46.30% | 62 | 93 | $790M |
| 123 | VSTM | Verastem, Inc. | Health Care | 0.21% | $7.24 | +3.35% | +14.75% | +62.01% | 62 | 35 | $500M |
| 124 | IRWD | Ironwood Pharmaceuticals, Inc. - Class A | Health Care | 0.21% | $4.34 | +6.17% | +18.33% | +11.99% | 55 | 99 | $696M |
| 125 | DMRA | Damora Therapeutics, Inc. Ordinary Shares | Health Care | 0.20% | $30.97 | +1.22% | +2.13% | +21.56% | 53 | 0 | $1.8B |
| 126 | RGNX | REGENXBIO Inc. | Health Care | 0.20% | $9.01 | +10.61% | -11.34% | +41.20% | 40 | 60 | $638M |
| 127 | OCGN | Ocugen, Inc. Common Stock | Health Care | 0.18% | $1.40 | +2.94% | +12.00% | +3.70% | 54 | 86 | $424M |
| 128 | SVRA | Savara Inc. | Health Care | 0.16% | $5.67 | +0.72% | +0.72% | +11.55% | 51 | 94 | $1.1B |
| 129 | ABUS | Arbutus Biopharma Corporation Common Stock | Health Care | 0.16% | $5.19 | -0.19% | +17.91% | +19.27% | 66 | 88 | $857M |
| 130 | PRME | Prime Medicine, Inc. Common Stock | Health Care | 0.16% | $3.66 | +14.00% | +24.92% | +23.26% | 61 | 64 | $508M |
| 131 | CABA | Cabaletta Bio, Inc. Common Stock | Health Care | 0.15% | $3.21 | +3.71% | +18.82% | -12.97% | 65 | 96 | $437M |
| 132 | CMPX | Compass Therapeutics, Inc. Common Stock | Health Care | 0.15% | $2.52 | +5.00% | +19.91% | +24.02% | 66 | 39 | $344M |
| 133 | CAPR | Capricor Therapeutics Inc | Health Care | 0.14% | $8.22 | +22.13% | -58.07% | -71.97% | 45 | 69 | $223M |
| 134 | OVID | Ovid Therapeutics Inc. Common Stock | Health Care | 0.12% | $2.90 | +3.55% | +23.83% | +18.78% | 63 | 98 | $435M |
| 135 | PRTA | Prothena Corporation plc Ordinary Shares | Health Care | 0.12% | $9.45 | +0.43% | +6.08% | -4.27% | 59 | 60 | $436M |
| 136 | CATX | Perspective Therapeutics, Inc. | Health Care | 0.12% | $3.20 | +3.13% | +11.53% | -18.36% | 55 | 39 | $332M |
| 137 | MDXG | MiMedx Group, Inc | Health Care | 0.12% | $4.34 | +1.87% | +2.36% | +19.89% | 55 | 29 | $622M |
| 138 | SPRY | ARS Pharmaceuticals, Inc. Common Stock | Health Care | 0.12% | $5.78 | +7.29% | -4.67% | -27.59% | 44 | 24 | $542M |
| 139 | VNDA | Vanda Pharmaceuticals Inc. | Health Care | 0.11% | $5.50 | +1.88% | +5.02% | -12.26% | 52 | 74 | $315M |
| 140 | LXEO | Lexeo Therapeutics, Inc. Common Stock | Health Care | 0.11% | $5.05 | +4.07% | +9.15% | -0.58% | 58 | 57 | $324M |
| 141 | ACHV | Achieve Life Sciences, Inc. | Health Care | 0.10% | $8.23 | +3.15% | +32.20% | +77.61% | 70 | 98 | $659M |
| 142 | SGMT | Sagimet Biosciences Inc. Series A Common Stock | Health Care | 0.09% | $10.29 | +0.78% | +44.52% | +43.51% | 69 | 87 | $442M |
| 143 | MYGN | Myriad Genetics Inc | Health Care | 0.09% | $3.21 | +5.25% | -44.04% | -16.71% | 37 | 27 | $289M |
| 144 | EBS | Emergent Biosolutions, Inc. | Health Care | 0.08% | $5.62 | +6.91% | -23.37% | -33.96% | 46 | 28 | $373M |
| 145 | BBOT | BridgeBio Oncology Therapeutics, Inc. Common Stock | Health Care | 0.07% | $9.26 | +2.52% | +4.11% | +9.59% | 57 | 43 | $648M |
| 146 | MPLT | MapLight Therapeutics, Inc. Common Stock | Health Care | 0.05% | $12.23 | +10.12% | -3.39% | -55.63% | 36 | 0 | $569M |
| 147 | SION | Sionna Therapeutics, Inc. Common Stock | Health Care | 0.03% | $6.14 | +11.81% | -86.42% | -85.00% | 24 | 22 | $2.2B |
XBI Holdings FAQ
What is the XBI ETF?
XBI is State Street SPDR S&P Biotech ETF, an exchange-traded fund holding 147 stocks weighted by market capitalization. It packages its underlying basket of companies into a single security, giving investors diversified exposure in one trade.
What are the top holdings of XBI?
The five largest XBI holdings by weight are currently MRNA, TWST, ORKA, APGE, KYMR. Because XBI is market-cap weighted, its biggest constituents carry the largest weights and have the most influence on the fund's daily moves.
How many stocks does XBI hold?
This snapshot lists 147 holdings for XBI. The count shifts as the fund is rebalanced or reconstituted and as share classes are included.
How concentrated is XBI?
The top 10 XBI holdings account for roughly 15.7% of the fund. Market-cap weighting means a small group of the largest companies can drive a meaningful share of performance.
Which sector does XBI weight the most?
Health Care is the largest sector weight in XBI at about 99.3% across 146 holdings. Sector weights shift over time as constituent prices and membership change.
How often do XBI holdings change?
XBI holdings update as the fund is rebalanced or reconstituted and as daily price moves shift each constituent's market-cap weight. The list on this page reflects the latest available holdings snapshot.